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- W1525758144 abstract "We report a new technique for non-invasively mapping the refractive index distribution through the eye lens using magneticresonance micro-imaging. The technique is applied to map the refractive index distribution throughout the sagittal plane of 18human eye lenses ranging in age from 14 to 82 years in vitro. The results are compared with standard models for the human eye lens.They confirm that the refractive index distribution, when plotted as a function of normalised lens radius, is a function of lens age anddiffers both between the equatorial and axial directions and between the anterior and posterior halves of the optical axis. The refractiveindex of the lens nucleus exhibits a significant reduction with age amounting to 3:4 0:6 104 years1. The contribution ofthe gradient index (GRIN) to the lens power decreases by 0:286 0:067 D/year, accounting almost entirely for the estimated overallchange in lens power with age for these lenses, which were probably in their most accommodated state. The results provide experimentalverification of hypothesised changes in the GRIN that have previously been invoked as contributing to presbyopia andsupport the hypothesis that changes in the GRIN are sufficient to offset effects of increasing curvature of human lenses with age intheir unaccommodated state." @default.
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- W1525758144 date "2002-06-01" @default.
- W1525758144 modified "2023-09-26" @default.
- W1525758144 title "Age-related changes in refractive index distribution and power of the human lens as measured by magnetic resonance micro-imaging in vitro" @default.
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