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- W1525759816 abstract "J Oral Pathol Med (2012) 41 : 340–347 Background: Periodontal ligament (PDL) cells are the main cellular constituents of the periodontium, maintain the integrity of the connective tissue, and impact pathology in periodontitis. The aim of this study was to analyze whether PDL cells recognize foreign particles and participate in the immune response to periodontal pathogens. Methods: Expression of surface proteins characteristic of antigen‐presenting cells (APCs) (major histocompatibility complex [MHC] class II, CD40, CD80, CD86) was analyzed in PDL cells after challenge with the cytokines interleukin (IL)‐1β, IL‐17A, and interferon‐gamma (IFN‐γ) or with heat‐killed Aggregatibacter actinomycetemcomitans using real‐time PCR and flow cytometry. Confocal laser scanning microscopy, transmitted light microscopy, flow cytometry, and time‐lapse microscopy were applied to analyze their phagocytotic capacity of collagen ( carboxylate‐modified microspheres ), non‐periodontal ( Escherichia coli ) and periodontal ( Aggregatibacter actinomycetemcomitans ) pathogens. Furthermore, it was examined whether cytokine activation of PDL cells affects the phagocytosis of collagen or bacteria. Results: PDL cells upregulated MHC class II after cytokine stimulation on transcriptional level, whereas co‐stimulatory molecules characteristic of professional APCs were not induced. Analyses on protein level revealed that MHC class II was not constitutively expressed in all PDL cell lines used. PDL cells phagocytosed both collagen and bacteria via acidic vesicles, suggesting the formation of phagosomes. Phagocytosis could be partially inhibited by inhibitors of phagocytosis, i.e., dynasore and wortmannin. Pre‐incubation with cytokines did not further enhance the phagocytosis rate of collagen or bacteria. Conclusions: These results suggest that PDL cells do not only represent bystanders in periodontal infections, but display non‐professional APC characteristics, suggesting possible participation in immune reactions of the oral cavity." @default.
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- W1525759816 date "2011-09-22" @default.
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- W1525759816 title "Antigen-presenting cell marker expression and phagocytotic activity in periodontal ligament cells" @default.
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- W1525759816 doi "https://doi.org/10.1111/j.1600-0714.2011.01086.x" @default.
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