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• W1525796871 abstract "In all mammals, including humans, the immune system is responsible for the protection against potentially hazardous pathogens, such as bacteria, viruses, parasites and fungi. In this remarkably effective defense system leukocytes, which mediate both innate and adaptive immune responses, play a central role. The innate immune system comprises granulocytes (neutrophils, eosinophils and basophils), natural killer (NK) cells, mast cells and macrophages. These cells are the first line of defense and provide the immediate response against pathogens. Neutrophils and macrophages can eliminate a pathogen directly by phagocytosis. Moreover, their pattern-recognition receptors, recognizing structurally conserved molecules derived from microbes such as bacterial lipopolysaccharides, unmethylated CpG, or viral double-stranded RNA, allow them to respond to a wide variety of microbial invaders, e.g. by producing cytokines that activate T lymphocytes of the adaptive immune system. Acquired or adaptive immunity is characterized by a slower but highly specific immune response. Three major cell types are involved in adaptive immunity: antigen presenting cells (APCs), T lymphocytes and B lymphocytes. Dendritic cells (DCs) are the most potent APCs. They act as messengers between the innate and the adaptive immune system by taking up, processing and presenting antigens to T lymphocytes. In response to presented antigens, T lymphocytes may react in different ways: CD4+ T helper cells produce various cytokines that direct the immune response, whereas CD8+ cytotoxic T cells produce toxic granules that induce death of infected cells. B cells are able to respond to pathogens by terminal differentiation into plasma cells after which they produce large quantities of antibodies. Modulation of B cell function and antibody production by CD4+ T cells is an important step in coordinating immune responses. Upon activation, B cells can migrate to germinal centers, which are specialized structures in secondary lymphoid organs, where they interact with T cells and DCs. Costimulatory signals from T cells then facilitate selection of B cells with high affinity for immunoglobulins and control class switching of the immunoglobulin (Ig) to IgG, IgA and IgE. Following pathogen elimination, lymphocytes leave a lasting legacy of the antigens they have come across represented by memory cells. As a result, lymphocytes are able to mount a faster and stronger immune response in future encounters with the same antigen. Defective T cell function can increase susceptibility to infections, allergies and autoimmune diseases. T" @default.
• W1525796871 created "2016-06-24" @default.
• W1525796871 creator A5005308154 @default.
• W1525796871 creator A5015831905 @default.
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• W1525796871 creator A5032626967 @default.
• W1525796871 creator A5079455723 @default.
• W1525796871 creator A5091596437 @default.
• W1525796871 date "2012-03-02" @default.
• W1525796871 modified "2023-09-24" @default.
• W1525796871 title "Interleukin-17 and T Helper 17 Cells in Mucosal Immunity of the Lung" @default.
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