Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525915127> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1525915127 endingPage "62" @default.
- W1525915127 startingPage "55" @default.
- W1525915127 abstract "When butyrate-treated HeLa cells are trypsinized and replated in the absence of butyrate, their neurite-like processes re-extend transiently. Process formation after replating is prevented when the cells are exposed to cycloheximide during butyrate treatment, whereas it is not prevented by prior exposure to the calcium ionophore A23187 plus butyrate. These results indicate that butyrate induces protein(s) required for process extension which can accumulate in the absence of processing and promote processing in the absence of inducer. Transient process re-extension is followed by spontaneous retraction of processes and reversion to normal morphology. Reversion is not prevented or delayed by puromycin. Surprisingly, however, cycloheximide completely prevents reversion even at low concentrations (< 0.5 μg/ml). Levels of the ganglioside sialolactosylceramide (GM3), synthesis of which is induced by butyrate, return to basal levels after removal of the inducer. Cycloheximide at 0.5 μg/ml prevents the decline of GM3 levels after removal of butyrate although the biosynthetic enzyme sialyltransferase decays at the same rate in the presence or absence of the drug and the activity of the sialidase is not affected. The results further support the hypothesis that the ganglioside GM3 is necessary for the morphological differentiation induced in HeLa cells by butyrate." @default.
- W1525915127 created "2016-06-24" @default.
- W1525915127 creator A5063084960 @default.
- W1525915127 creator A5087034581 @default.
- W1525915127 date "1976-11-01" @default.
- W1525915127 modified "2023-10-04" @default.
- W1525915127 title "Morphological and biochemical differentiation in HeLa cells" @default.
- W1525915127 cites W1967152830 @default.
- W1525915127 cites W2007667296 @default.
- W1525915127 cites W2009328288 @default.
- W1525915127 cites W2020075783 @default.
- W1525915127 cites W2022415916 @default.
- W1525915127 cites W2035692772 @default.
- W1525915127 cites W2049618391 @default.
- W1525915127 cites W2050036623 @default.
- W1525915127 cites W2092707511 @default.
- W1525915127 cites W2100805638 @default.
- W1525915127 cites W2135839082 @default.
- W1525915127 doi "https://doi.org/10.1016/0014-4827(76)90240-8" @default.
- W1525915127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/186290" @default.
- W1525915127 hasPublicationYear "1976" @default.
- W1525915127 type Work @default.
- W1525915127 sameAs 1525915127 @default.
- W1525915127 citedByCount "50" @default.
- W1525915127 countsByYear W15259151272015 @default.
- W1525915127 crossrefType "journal-article" @default.
- W1525915127 hasAuthorship W1525915127A5063084960 @default.
- W1525915127 hasAuthorship W1525915127A5087034581 @default.
- W1525915127 hasConcept C100544194 @default.
- W1525915127 hasConcept C104317684 @default.
- W1525915127 hasConcept C127716648 @default.
- W1525915127 hasConcept C153911025 @default.
- W1525915127 hasConcept C2225953 @default.
- W1525915127 hasConcept C2775999725 @default.
- W1525915127 hasConcept C2776979534 @default.
- W1525915127 hasConcept C2778128677 @default.
- W1525915127 hasConcept C2778942008 @default.
- W1525915127 hasConcept C2779200571 @default.
- W1525915127 hasConcept C3675279 @default.
- W1525915127 hasConcept C55493867 @default.
- W1525915127 hasConcept C70883133 @default.
- W1525915127 hasConcept C86803240 @default.
- W1525915127 hasConcept C95444343 @default.
- W1525915127 hasConceptScore W1525915127C100544194 @default.
- W1525915127 hasConceptScore W1525915127C104317684 @default.
- W1525915127 hasConceptScore W1525915127C127716648 @default.
- W1525915127 hasConceptScore W1525915127C153911025 @default.
- W1525915127 hasConceptScore W1525915127C2225953 @default.
- W1525915127 hasConceptScore W1525915127C2775999725 @default.
- W1525915127 hasConceptScore W1525915127C2776979534 @default.
- W1525915127 hasConceptScore W1525915127C2778128677 @default.
- W1525915127 hasConceptScore W1525915127C2778942008 @default.
- W1525915127 hasConceptScore W1525915127C2779200571 @default.
- W1525915127 hasConceptScore W1525915127C3675279 @default.
- W1525915127 hasConceptScore W1525915127C55493867 @default.
- W1525915127 hasConceptScore W1525915127C70883133 @default.
- W1525915127 hasConceptScore W1525915127C86803240 @default.
- W1525915127 hasConceptScore W1525915127C95444343 @default.
- W1525915127 hasIssue "1" @default.
- W1525915127 hasLocation W15259151271 @default.
- W1525915127 hasLocation W15259151272 @default.
- W1525915127 hasOpenAccess W1525915127 @default.
- W1525915127 hasPrimaryLocation W15259151271 @default.
- W1525915127 hasRelatedWork W1525915127 @default.
- W1525915127 hasRelatedWork W1599027486 @default.
- W1525915127 hasRelatedWork W1762485948 @default.
- W1525915127 hasRelatedWork W1984087047 @default.
- W1525915127 hasRelatedWork W1992083144 @default.
- W1525915127 hasRelatedWork W2000984107 @default.
- W1525915127 hasRelatedWork W2021461380 @default.
- W1525915127 hasRelatedWork W2022337075 @default.
- W1525915127 hasRelatedWork W2032532871 @default.
- W1525915127 hasRelatedWork W2092988039 @default.
- W1525915127 hasVolume "103" @default.
- W1525915127 isParatext "false" @default.
- W1525915127 isRetracted "false" @default.
- W1525915127 magId "1525915127" @default.
- W1525915127 workType "article" @default.