Matches in SemOpenAlex for { <https://semopenalex.org/work/W15260436> ?p ?o ?g. }
- W15260436 abstract "Disuse osteoporosis is a problem for people with spinal cord injury or stroke, patients confined to bed rest, and astronauts exposed to microgravity. Unlike most mammals however, bears have been shown to prevent bone loss during hibernation, a seasonal period of disuse. Similarly, studies in ground squirrels indicate preservation of whole bone strength during hibernation, though evidence suggests there may be some increased osteocytic osteolysis. Uncovering the mechanism by which these animals prevent bone loss during hibernation could lead to an improved treatment for osteoporosis in humans. Marmots are a good animal model for these studies because they are small enough to easily house in an animal facility yet still utilize intracortical remodeling like humans and bears, and unlike smaller rodents like squirrels. Marmots preserve bone mechanical and microstructural properties during hibernation. Bone mechanical and geometrical properties are not diminished in post-hibernation samples compared to pre-hibernation samples. Mineral content, measured by ash fraction, was higher in post-hibernation samples (p = 0.0003). Haversian porosity as well as remodeling cavity density were not different (p > 0.38) between pre- and post-hibernation samples. Similarly, average lacunar area, lacunar density, and lacunar porosity were all lower (p < 0.0001) in post-hibernation samples. Trabecular thickness was larger in posthibernation samples (p = 0.0058). Bone volume fraction was not different between groups, but approached significance (p = 0.0725). Further studies in marmots and other hibernators could help uncover the mechanism that allows hibernators to prevent disuse osteoporosis during hibernation." @default.
- W15260436 created "2016-06-24" @default.
- W15260436 creator A5017093605 @default.
- W15260436 date "2020-12-10" @default.
- W15260436 modified "2023-10-18" @default.
- W15260436 title "Effects of hibernation on bone in yellow-bellied marmots" @default.
- W15260436 cites W122585317 @default.
- W15260436 cites W1452930411 @default.
- W15260436 cites W1515194703 @default.
- W15260436 cites W1526826623 @default.
- W15260436 cites W1565135627 @default.
- W15260436 cites W161440572 @default.
- W15260436 cites W1809648194 @default.
- W15260436 cites W1888774673 @default.
- W15260436 cites W1891376806 @default.
- W15260436 cites W1955559333 @default.
- W15260436 cites W1963628384 @default.
- W15260436 cites W1964272141 @default.
- W15260436 cites W1964773823 @default.
- W15260436 cites W1964908886 @default.
- W15260436 cites W1965136488 @default.
- W15260436 cites W1968643626 @default.
- W15260436 cites W1969314848 @default.
- W15260436 cites W1973830769 @default.
- W15260436 cites W1974091707 @default.
- W15260436 cites W1974432627 @default.
- W15260436 cites W1975923534 @default.
- W15260436 cites W1976928448 @default.
- W15260436 cites W1979297783 @default.
- W15260436 cites W1980558290 @default.
- W15260436 cites W1980982954 @default.
- W15260436 cites W1983057999 @default.
- W15260436 cites W1984941837 @default.
- W15260436 cites W1986906848 @default.
- W15260436 cites W1987577114 @default.
- W15260436 cites W1988425215 @default.
- W15260436 cites W1992039661 @default.
- W15260436 cites W1992567157 @default.
- W15260436 cites W1993035292 @default.
- W15260436 cites W1993467351 @default.
- W15260436 cites W1994672506 @default.
- W15260436 cites W1994699261 @default.
- W15260436 cites W1995565902 @default.
- W15260436 cites W1996007424 @default.
- W15260436 cites W1997729832 @default.
- W15260436 cites W1998183419 @default.
- W15260436 cites W2002694482 @default.
- W15260436 cites W2003162584 @default.
- W15260436 cites W2003890323 @default.
- W15260436 cites W2004270193 @default.
- W15260436 cites W2008718896 @default.
- W15260436 cites W2010365652 @default.
- W15260436 cites W2012800209 @default.
- W15260436 cites W2013950171 @default.
- W15260436 cites W2022596308 @default.
- W15260436 cites W2024191310 @default.
- W15260436 cites W2024480270 @default.
- W15260436 cites W2027308735 @default.
- W15260436 cites W2028092717 @default.
- W15260436 cites W2029718981 @default.
- W15260436 cites W2033587429 @default.
- W15260436 cites W2034090700 @default.
- W15260436 cites W2034975399 @default.
- W15260436 cites W2037749753 @default.
- W15260436 cites W2040078170 @default.
- W15260436 cites W2040645421 @default.
- W15260436 cites W2040963365 @default.
- W15260436 cites W2043833615 @default.
- W15260436 cites W2046268652 @default.
- W15260436 cites W2046420639 @default.
- W15260436 cites W2048095146 @default.
- W15260436 cites W2048259913 @default.
- W15260436 cites W2049418136 @default.
- W15260436 cites W2052204645 @default.
- W15260436 cites W2054040811 @default.
- W15260436 cites W2056885783 @default.
- W15260436 cites W2057332307 @default.
- W15260436 cites W2061242942 @default.
- W15260436 cites W2062138695 @default.
- W15260436 cites W2064341383 @default.
- W15260436 cites W2066297986 @default.
- W15260436 cites W2066676148 @default.
- W15260436 cites W2068682682 @default.
- W15260436 cites W2070693900 @default.
- W15260436 cites W2072013523 @default.
- W15260436 cites W2077951824 @default.
- W15260436 cites W2079327979 @default.
- W15260436 cites W2079446976 @default.
- W15260436 cites W2080283284 @default.
- W15260436 cites W2081877806 @default.
- W15260436 cites W2083060255 @default.
- W15260436 cites W2090506996 @default.
- W15260436 cites W2091409940 @default.
- W15260436 cites W2094077819 @default.
- W15260436 cites W2095921442 @default.
- W15260436 cites W2099054178 @default.
- W15260436 cites W2102105454 @default.
- W15260436 cites W2102163839 @default.
- W15260436 cites W2103411930 @default.
- W15260436 cites W2108764122 @default.