FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526067645> ?p ?o ?g. }

• W1526067645 endingPage "11176" @default.
• W1526067645 startingPage "11170" @default.
• W1526067645 abstract "Vitronectin (Vn) is not only a major adhesive glycoprotein present in platelets but also regulates proteolytic enzyme cascades, including the blood coagulation, fibrinolytic, and complement systems. In human platelet lysates prepared by freeze-thawing or by the addition of nonionic detergent, the Vn antigen content was drastically reduced in comparison with lysates prepared in the presence of SDS, suggesting that Vn is hydrolyzed by platelet-associated enzymes. Exogenously added purified human Vn and Vn present in plasma were also cleaved by these enzyme systems. Degradation was mediated by a nonsecreted or membrane-associated protease system that was inhibited by E-64, EDTA, and leupeptin but not inhibitors of serine and aspartic proteases, suggesting an involvement of calcium-dependent cysteine proteases. Consistently, calpastatin inhibited the hydrolysis of Vn, suggesting that Vn is a substrate for calpain. This was confirmed in a purified system. Vn was cleaved by calpains I and II in a dose- and time-dependent manner, resulting in defined Vn fragments with similar electrophoretic mobility in comparison with those detected in platelet lysates. Functional characterization of the calpain-hydrolyzed Vn revealed that while the type 1 plasminogen activator inhibitor binding activity was unchanged, the heparin and cell binding functions were destroyed. These results suggest that calpains released upon platelet membrane damage or upon tissue injury and necrosis differentially regulate functional domains of the Vn molecule." @default.
• W1526067645 created "2016-06-24" @default.
• W1526067645 creator A5026463840 @default.
• W1526067645 date "1996-05-01" @default.
• W1526067645 modified "2023-09-27" @default.
• W1526067645 title "Hydrolysis of Platelet Vitronectin by Calpain" @default.
• W1526067645 cites W1498287490 @default.
• W1526067645 cites W1511176863 @default.
• W1526067645 cites W1532207110 @default.
• W1526067645 cites W1539115017 @default.
• W1526067645 cites W1541514685 @default.
• W1526067645 cites W1548286725 @default.
• W1526067645 cites W1562197596 @default.
• W1526067645 cites W1590202185 @default.
• W1526067645 cites W1601891991 @default.
• W1526067645 cites W1608293130 @default.
• W1526067645 cites W1872169445 @default.
• W1526067645 cites W1981019360 @default.
• W1526067645 cites W1993981607 @default.
• W1526067645 cites W1995780398 @default.
• W1526067645 cites W2014316985 @default.
• W1526067645 cites W2029890215 @default.
• W1526067645 cites W2032740965 @default.
• W1526067645 cites W2051958715 @default.
• W1526067645 cites W2066279385 @default.
• W1526067645 cites W2097346736 @default.
• W1526067645 cites W2100837269 @default.
• W1526067645 cites W2111853402 @default.
• W1526067645 cites W2155133540 @default.
• W1526067645 cites W2177719047 @default.
• W1526067645 cites W2235497272 @default.
• W1526067645 cites W2345436650 @default.
• W1526067645 doi "https://doi.org/10.1074/jbc.271.19.11170" @default.
• W1526067645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8626663" @default.
• W1526067645 hasPublicationYear "1996" @default.
• W1526067645 type Work @default.
• W1526067645 sameAs 1526067645 @default.
• W1526067645 citedByCount "8" @default.
• W1526067645 crossrefType "journal-article" @default.
• W1526067645 hasAuthorship W1526067645A5026463840 @default.
• W1526067645 hasConcept C108625454 @default.
• W1526067645 hasConcept C1491633281 @default.
• W1526067645 hasConcept C164144092 @default.
• W1526067645 hasConcept C181199279 @default.
• W1526067645 hasConcept C182220744 @default.
• W1526067645 hasConcept C185592680 @default.
• W1526067645 hasConcept C203014093 @default.
• W1526067645 hasConcept C2775883766 @default.
• W1526067645 hasConcept C2776414213 @default.
• W1526067645 hasConcept C2776714187 @default.
• W1526067645 hasConcept C2777488010 @default.
• W1526067645 hasConcept C2777807008 @default.
• W1526067645 hasConcept C2781071845 @default.
• W1526067645 hasConcept C55493867 @default.
• W1526067645 hasConcept C56928146 @default.
• W1526067645 hasConcept C86492073 @default.
• W1526067645 hasConcept C86803240 @default.
• W1526067645 hasConcept C89560881 @default.
• W1526067645 hasConceptScore W1526067645C108625454 @default.
• W1526067645 hasConceptScore W1526067645C1491633281 @default.
• W1526067645 hasConceptScore W1526067645C164144092 @default.
• W1526067645 hasConceptScore W1526067645C181199279 @default.
• W1526067645 hasConceptScore W1526067645C182220744 @default.
• W1526067645 hasConceptScore W1526067645C185592680 @default.
• W1526067645 hasConceptScore W1526067645C203014093 @default.
• W1526067645 hasConceptScore W1526067645C2775883766 @default.
• W1526067645 hasConceptScore W1526067645C2776414213 @default.
• W1526067645 hasConceptScore W1526067645C2776714187 @default.
• W1526067645 hasConceptScore W1526067645C2777488010 @default.
• W1526067645 hasConceptScore W1526067645C2777807008 @default.
• W1526067645 hasConceptScore W1526067645C2781071845 @default.
• W1526067645 hasConceptScore W1526067645C55493867 @default.
• W1526067645 hasConceptScore W1526067645C56928146 @default.
• W1526067645 hasConceptScore W1526067645C86492073 @default.
• W1526067645 hasConceptScore W1526067645C86803240 @default.
• W1526067645 hasConceptScore W1526067645C89560881 @default.
• W1526067645 hasIssue "19" @default.
• W1526067645 hasLocation W15260676451 @default.
• W1526067645 hasOpenAccess W1526067645 @default.
• W1526067645 hasPrimaryLocation W15260676451 @default.
• W1526067645 hasRelatedWork W1534966313 @default.
• W1526067645 hasRelatedWork W1546308520 @default.
• W1526067645 hasRelatedWork W1594492118 @default.
• W1526067645 hasRelatedWork W1971874584 @default.
• W1526067645 hasRelatedWork W1976756990 @default.
• W1526067645 hasRelatedWork W1977846928 @default.
• W1526067645 hasRelatedWork W1979466955 @default.
• W1526067645 hasRelatedWork W1986167466 @default.
• W1526067645 hasRelatedWork W2010091903 @default.
• W1526067645 hasRelatedWork W2025834512 @default.
• W1526067645 hasRelatedWork W203068383 @default.
• W1526067645 hasRelatedWork W2032859390 @default.
• W1526067645 hasRelatedWork W2033813400 @default.
• W1526067645 hasRelatedWork W2045139373 @default.
• W1526067645 hasRelatedWork W2052456475 @default.
• W1526067645 hasRelatedWork W2052474184 @default.
• W1526067645 hasRelatedWork W2070195100 @default.
• W1526067645 hasRelatedWork W2073945398 @default.

• next