FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W152606951> ?p ?o ?g. }

• W152606951 abstract "Measures of perfusion adequacy in perfused rat hemicorpus preparations were investigated as potential indices of tissue function during studies of muscle protein metabolism. Perfusion under normal conditions for up to 80 min resulted in rates of protein synthesis and concentrations of ATP in muscle that were similar to those in vivo, but phosphocreatine in muscle gradually decreased and muscle lactate increased. Hypoxic conditions led to lower rates of protein synthesis, lower phospho-creatine and raised lactate contents in muscle compared with normal perfusions, and ATP was slightly decreased. Hypoxic preparations also released more lactate and K+ into the medium and had higher perfusion pressures, but glucose uptake and muscle water content were not altered. In totally ischaemic muscle, concentrations of ATP and phosphocreatine were even lower than in hypoxic muscle, and that of lactate was higher. From 11 preparations perfused for 60 min under normal conditions, three were selected on the basis of lower muscle ATP content than the others. Preparations with low ATP also showed lower muscle phosphocreatine concentrations, O2 uptake and CO2 output, as well as higher perfusion pressure and muscle lactate concentrations than in the remaining preparations, but muscle water, ADP and AMP concentrations and lactate and K+ flux were no different. In perfusions extended to 3 h, deterioration of function was more apparent. There were significant correlations between rates of protein synthesis and the concentrations of ATP, phosphocreatine and lactate in two different muscles (r = 0.756-0.929), but not with any of the other indices investigated. Taken overall, these experiments showed that concentrations of ADP, AMP and water in muscle, rates of lactate and glucose metabolism, K+ output, perfusion pressure and blood gas parameters were unsuitable for distinguishing unsound from sound preparations, because they did not consistently demonstrate differences, or could not be ascribed to only muscle metabolism. It was found that ATP, phosphocreatine and lactate concentrations in muscle were the best indicators of impaired metabolic state in studies of protein synthesis. Measurements of these could be used on a routine basis for rejecting unsatisfactory preparations." @default.
• W152606951 created "2016-06-24" @default.
• W152606951 creator A5030829931 @default.
• W152606951 creator A5036792360 @default.
• W152606951 creator A5072667584 @default.
• W152606951 date "1984-03-01" @default.
• W152606951 modified "2023-09-26" @default.
• W152606951 title "The metabolic state of muscle in the isolated perfused rat hemicorpus in relation to rates of protein synthesis" @default.
• W152606951 cites W160192309 @default.
• W152606951 cites W1733705378 @default.
• W152606951 cites W180374030 @default.
• W152606951 cites W1823474520 @default.
• W152606951 cites W1874250917 @default.
• W152606951 cites W1888946747 @default.
• W152606951 cites W1965117913 @default.
• W152606951 cites W1974958023 @default.
• W152606951 cites W1983454434 @default.
• W152606951 cites W2017720242 @default.
• W152606951 cites W2018683948 @default.
• W152606951 cites W2019633512 @default.
• W152606951 cites W2029788137 @default.
• W152606951 cites W2042948145 @default.
• W152606951 cites W2053495088 @default.
• W152606951 cites W2057365575 @default.
• W152606951 cites W2070424116 @default.
• W152606951 cites W2073292279 @default.
• W152606951 cites W2091454330 @default.
• W152606951 cites W2093543136 @default.
• W152606951 cites W2095389831 @default.
• W152606951 cites W2113815687 @default.
• W152606951 cites W2140656200 @default.
• W152606951 cites W2208272755 @default.
• W152606951 cites W2250649829 @default.
• W152606951 cites W2313131185 @default.
• W152606951 cites W2335707566 @default.
• W152606951 cites W2341504784 @default.
• W152606951 cites W2341718345 @default.
• W152606951 cites W2394686715 @default.
• W152606951 cites W2411447712 @default.
• W152606951 cites W2417418988 @default.
• W152606951 cites W314630959 @default.
• W152606951 cites W85283893 @default.
• W152606951 doi "https://doi.org/10.1042/bj2180429" @default.
• W152606951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1153357" @default.
• W152606951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6424660" @default.
• W152606951 hasPublicationYear "1984" @default.
• W152606951 type Work @default.
• W152606951 sameAs 152606951 @default.
• W152606951 citedByCount "19" @default.
• W152606951 crossrefType "journal-article" @default.
• W152606951 hasAuthorship W152606951A5030829931 @default.
• W152606951 hasAuthorship W152606951A5036792360 @default.
• W152606951 hasAuthorship W152606951A5072667584 @default.
• W152606951 hasBestOaLocation W1526069512 @default.
• W152606951 hasConcept C126322002 @default.
• W152606951 hasConcept C134018914 @default.
• W152606951 hasConcept C146957229 @default.
• W152606951 hasConcept C185592680 @default.
• W152606951 hasConcept C2778626300 @default.
• W152606951 hasConcept C2779564974 @default.
• W152606951 hasConcept C2779896295 @default.
• W152606951 hasConcept C2779959927 @default.
• W152606951 hasConcept C2986317502 @default.
• W152606951 hasConcept C55493867 @default.
• W152606951 hasConcept C62231903 @default.
• W152606951 hasConcept C71924100 @default.
• W152606951 hasConcept C86803240 @default.
• W152606951 hasConceptScore W152606951C126322002 @default.
• W152606951 hasConceptScore W152606951C134018914 @default.
• W152606951 hasConceptScore W152606951C146957229 @default.
• W152606951 hasConceptScore W152606951C185592680 @default.
• W152606951 hasConceptScore W152606951C2778626300 @default.
• W152606951 hasConceptScore W152606951C2779564974 @default.
• W152606951 hasConceptScore W152606951C2779896295 @default.
• W152606951 hasConceptScore W152606951C2779959927 @default.
• W152606951 hasConceptScore W152606951C2986317502 @default.
• W152606951 hasConceptScore W152606951C55493867 @default.
• W152606951 hasConceptScore W152606951C62231903 @default.
• W152606951 hasConceptScore W152606951C71924100 @default.
• W152606951 hasConceptScore W152606951C86803240 @default.
• W152606951 hasLocation W1526069511 @default.
• W152606951 hasLocation W1526069512 @default.
• W152606951 hasLocation W1526069513 @default.
• W152606951 hasLocation W1526069514 @default.
• W152606951 hasOpenAccess W152606951 @default.
• W152606951 hasPrimaryLocation W1526069511 @default.
• W152606951 hasRelatedWork W1964138035 @default.
• W152606951 hasRelatedWork W1969935890 @default.
• W152606951 hasRelatedWork W1982708348 @default.
• W152606951 hasRelatedWork W2029673259 @default.
• W152606951 hasRelatedWork W2034805757 @default.
• W152606951 hasRelatedWork W2064355103 @default.
• W152606951 hasRelatedWork W2116160593 @default.
• W152606951 hasRelatedWork W4230030006 @default.
• W152606951 hasRelatedWork W2337588140 @default.
• W152606951 hasRelatedWork W2977381691 @default.
• W152606951 isParatext "false" @default.
• W152606951 isRetracted "false" @default.
• W152606951 magId "152606951" @default.
• W152606951 workType "article" @default.