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- W1526082783 abstract "This chapter surveys the current practice in the selection of animal tumors for the studies of therapeutic agencies for cancer. It examines the status of these tumors as models of naturally occurring cancers in man by reference to the criteria of eligibility or disqualification imposed by their mode of origin or conditions of transplantation. Cancer is distinguishable from all other categories of human disease in that its general biological features are faithfully represented in naturally occurring cancers of small mammals suitable for laboratory investigations. No species specification is required for the definition of the carcinogenic potential of a chemical or physical agent. Also the mode of growth and pattern of spread of the disease are closely similar in the different mammalian species, and the restraint of tumor growth is affected by similar agencies and by similar mechanisms in different species. Therefore, a great part of cancer research using animal tumors is directed to the elucidation of general biological problems, neoplastic tissue being a convenient material for the investigation. The chapter considers the usage of animal tumors, with experiments undertaken to elucidate problems intrinsic to naturally occurring cancer, which envisage clinical relevance, or the results of which provide instigation for clinical application." @default.
- W1526082783 created "2016-06-24" @default.
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- W1526082783 date "1978-01-01" @default.
- W1526082783 modified "2023-10-11" @default.
- W1526082783 title "The Choice of Animal Tumors for Experimental Studies of Cancer Therapy" @default.
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- W1526082783 doi "https://doi.org/10.1016/s0065-230x(08)60932-x" @default.
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