FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526121547> ?p ?o ?g. }

• W1526121547 endingPage "5843" @default.
• W1526121547 startingPage "5833" @default.
• W1526121547 abstract "STAT-induced STAT inhibitor-1 (SSI-1), also referred to as suppressor of cytokine signaling-1 and JAK-binding protein, is a member of a new family, the members of which are negative regulators of cytokine signals. SSI-1 is induced by various cytokines; however, the transcriptional mechanism of the SSI-1 gene is not fully understood. Here, we showed that transcription of the mouse SSI-1 gene was initiated from six adjoining sites accompanying three GC boxes and a single GC box-like element near them, but not from the TATA box or an initiator sequence. We also showed that IFN-gamma induced SSI-1 mRNA more strongly than IL-6 in NIH-3T3 fibroblasts and that this IFN-gamma effect was mediated by Stat1. To determine the signal pathway downstream of Stat1, transcriptional activities of several mutant promoters were examined. The region mediating stimulatory effect of IFN-gamma to the gene transcription was localized to the -88/-60 region containing three tandem GAAA units, named variant IFN-gamma-responsive element (VIRE), while four IFN-gamma activation site (GAS)-like elements located far upstream were not related to the IFN-gamma response. Gel-shift assays revealed that IFN-gamma induced IFN regulatory factor-1 (IRF-1) binding to VIRE, but not that of IRF-2 or three components of ISGF3. Furthermore, forced expression of IRF-1 mimicked and that of IRF-2 inhibited the stimulatory effect of IFN-gamma on SSI-1 gene transcription. Finally, mouse embryonal fibroblasts lacking IRF-1 showed impaired SSI-1 mRNA induction by IFN-gamma. These results demonstrated that IRF-1, which is induced by activation of Stat1, mediated transcriptional activation of the SSI-1 gene by IFN-gamma via VIRE." @default.
• W1526121547 created "2016-06-24" @default.
• W1526121547 creator A5013910008 @default.
• W1526121547 creator A5018970596 @default.
• W1526121547 creator A5020771892 @default.
• W1526121547 creator A5021463605 @default.
• W1526121547 creator A5041682962 @default.
• W1526121547 creator A5080071993 @default.
• W1526121547 date "2000-06-01" @default.
• W1526121547 modified "2023-10-16" @default.
• W1526121547 title "IFN Regulatory Factor-1-Mediated Transcriptional Activation of Mouse STAT-Induced STAT Inhibitor-1 Gene Promoter by IFN-γ" @default.
• W1526121547 cites W11800597 @default.
• W1526121547 cites W1487582551 @default.
• W1526121547 cites W1488478985 @default.
• W1526121547 cites W1585646667 @default.
• W1526121547 cites W1602943807 @default.
• W1526121547 cites W1668039320 @default.
• W1526121547 cites W1964815717 @default.
• W1526121547 cites W1966312399 @default.
• W1526121547 cites W1978294812 @default.
• W1526121547 cites W1981765089 @default.
• W1526121547 cites W1982025886 @default.
• W1526121547 cites W1986378853 @default.
• W1526121547 cites W1997740207 @default.
• W1526121547 cites W2000618574 @default.
• W1526121547 cites W2007063498 @default.
• W1526121547 cites W2014237818 @default.
• W1526121547 cites W2029275361 @default.
• W1526121547 cites W2033417996 @default.
• W1526121547 cites W2055192078 @default.
• W1526121547 cites W2056627597 @default.
• W1526121547 cites W2070160790 @default.
• W1526121547 cites W2070886703 @default.
• W1526121547 cites W2078578981 @default.
• W1526121547 cites W2082390264 @default.
• W1526121547 cites W2088818068 @default.
• W1526121547 cites W2090162429 @default.
• W1526121547 cites W2119596771 @default.
• W1526121547 cites W2137145530 @default.
• W1526121547 cites W2142197101 @default.
• W1526121547 cites W2142830561 @default.
• W1526121547 cites W2144093304 @default.
• W1526121547 cites W2154161526 @default.
• W1526121547 cites W2167065653 @default.
• W1526121547 cites W2471882287 @default.
• W1526121547 cites W347895934 @default.
• W1526121547 cites W4236138196 @default.
• W1526121547 cites W4241534380 @default.
• W1526121547 doi "https://doi.org/10.4049/jimmunol.164.11.5833" @default.
• W1526121547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10820262" @default.
• W1526121547 hasPublicationYear "2000" @default.
• W1526121547 type Work @default.
• W1526121547 sameAs 1526121547 @default.
• W1526121547 citedByCount "92" @default.
• W1526121547 countsByYear W15261215472012 @default.
• W1526121547 countsByYear W15261215472013 @default.
• W1526121547 countsByYear W15261215472014 @default.
• W1526121547 countsByYear W15261215472015 @default.
• W1526121547 countsByYear W15261215472017 @default.
• W1526121547 countsByYear W15261215472021 @default.
• W1526121547 countsByYear W15261215472022 @default.
• W1526121547 countsByYear W15261215472023 @default.
• W1526121547 crossrefType "journal-article" @default.
• W1526121547 hasAuthorship W1526121547A5013910008 @default.
• W1526121547 hasAuthorship W1526121547A5018970596 @default.
• W1526121547 hasAuthorship W1526121547A5020771892 @default.
• W1526121547 hasAuthorship W1526121547A5021463605 @default.
• W1526121547 hasAuthorship W1526121547A5041682962 @default.
• W1526121547 hasAuthorship W1526121547A5080071993 @default.
• W1526121547 hasBestOaLocation W15261215471 @default.
• W1526121547 hasConcept C101762097 @default.
• W1526121547 hasConcept C104317684 @default.
• W1526121547 hasConcept C126042315 @default.
• W1526121547 hasConcept C132376346 @default.
• W1526121547 hasConcept C138885662 @default.
• W1526121547 hasConcept C14077384 @default.
• W1526121547 hasConcept C145430368 @default.
• W1526121547 hasConcept C150194340 @default.
• W1526121547 hasConcept C153911025 @default.
• W1526121547 hasConcept C165864922 @default.
• W1526121547 hasConcept C179185449 @default.
• W1526121547 hasConcept C179926584 @default.
• W1526121547 hasConcept C203014093 @default.
• W1526121547 hasConcept C2777003663 @default.
• W1526121547 hasConcept C2778277574 @default.
• W1526121547 hasConcept C2778690821 @default.
• W1526121547 hasConcept C2778923194 @default.
• W1526121547 hasConcept C2780841837 @default.
• W1526121547 hasConcept C32300475 @default.
• W1526121547 hasConcept C41895202 @default.
• W1526121547 hasConcept C54355233 @default.
• W1526121547 hasConcept C62478195 @default.
• W1526121547 hasConcept C65439459 @default.
• W1526121547 hasConcept C65888428 @default.
• W1526121547 hasConcept C86339819 @default.
• W1526121547 hasConcept C86803240 @default.
• W1526121547 hasConcept C9173399 @default.
• W1526121547 hasConcept C95444343 @default.

• next