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- W1526171897 abstract "Abstract Aim: To compare the efficacy of sublingual midazolam with oral morphine versus that of oral morphine with placebo in a paediatric population attending an emergency department (ED) with acute long‐bone fractures. Methods: A sample of children aged 5–16 years with clinically deformed closed long‐bone fractures was randomized to groups receiving either oral morphine (0.5 mg/kg)/sublingual placebo or oral morphine (0.5 mg/kg)/sublingual midazolam (0.2 mg/kg). The main exclusion criteria were narcotic or benzodiazepine use, significant head injury, multiple organ failure, femoral fracture and allergy. Pain scores were rated on a 100‐mm visual analogue scale (VAS) at 0, 15, 30, 60, 90 and 120 min. Results: Fifty‐eight children were enrolled (mean age: 10.5 years, SD 2.7). Fractures concerned the radius or ulna in 43 cases (74.1%), the humerus (22.4%) and the tibia or fibula (3.5%). No significant difference in VAS scores was observed between the two treatment arms (p = 0.72). Drowsiness was significantly more frequent in the midazolam group (p = 0.007) during the first 2 h after administration. No serious adverse event was observed. Conclusion: The analgesic performances of morphine and the combination of morphine with midazolam assessed by VAS were similar in children presenting at the ED with a long‐bone fracture." @default.
- W1526171897 created "2016-06-24" @default.
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- W1526171897 date "2011-05-11" @default.
- W1526171897 modified "2023-10-17" @default.
- W1526171897 title "Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study" @default.
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- W1526171897 doi "https://doi.org/10.1111/j.1651-2227.2011.02311.x" @default.
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