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- W1526303449 abstract "Infectious bronchitis virus (IBV) causes an economically important respiratory disease in poultry worldwide. Previous studies have shown that CD8+ cytotoxic T lymphocytes (CTL) are critical in controlling acute IBV infection, but the role of innate immunity is unknown. This study describes the in vitro and in vivo anti-IBV activity of natural spleen cell-derived and recombinant chicken interferon type I (rChIFN-α). Both natural and rChIFN-α inhibited replication of the Beaudette strain of IBV in chicken kidney cells (CKC) in a dose-dependent manner, with the antiviral activity of the former accounted for entirely by its content of type I IFN. IFN at 100 U/ml reduced viral replication by 50% as measured by syncytia formation. In addition, the spleen cell-derived supernatants (natural IFN) inhibited tracheal ring ciliostasis mediated by the Gray strain of IBV. Optimal protection against IBV-induced respiratory disease was obtained after intravenous or oral administration of ChIFN given 1 day before virus challenge and each of 5 days thereafter. ChIFN-I protected chicks from clinical illness by delaying the onset of the disease and decreasing the severity of illness, demonstrating its potential as an immune enhancer." @default.
- W1526303449 created "2016-06-24" @default.
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- W1526303449 date "2001-12-01" @default.
- W1526303449 modified "2023-10-16" @default.
- W1526303449 title "Chicken Interferon Type I Inhibits Infectious Bronchitis Virus Replication and Associated Respiratory Illness" @default.
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- W1526303449 doi "https://doi.org/10.1089/107999001317205204" @default.
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