FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526353609> ?p ?o ?g. }

• W1526353609 endingPage "853" @default.
• W1526353609 startingPage "845" @default.
• W1526353609 abstract "Crystal structures of the PDZ2 domain of the scaffolding protein syntenin, both unbound and in complexes with peptides derived from C termini of IL5 receptor (alpha chain) and syndecan, reveal the molecular roots of syntenin's degenerate specificity. Three distinct binding sites (S(0), S(-1), and S(-2)), with affinities for hydrophobic side chains, function in a combinatorial way: S(-1) and S(-2) act together to bind syndecan, while S(0) and S(-1) are involved in the binding of IL5Ralpha. Neither mode of interaction is consistent with the prior classification scheme, which defined the IL5Ralpha interaction as class I (-S/T-X-phi) and the syndecan interaction as class II (-phi-X-phi). These results, in conjunction with other emerging structural data on PDZ domains, call for a revision of their classification and of the existing model of their mechanism." @default.
• W1526353609 created "2016-06-24" @default.
• W1526353609 creator A5038550661 @default.
• W1526353609 creator A5042893936 @default.
• W1526353609 creator A5055855625 @default.
• W1526353609 creator A5080893332 @default.
• W1526353609 creator A5090502997 @default.
• W1526353609 date "2003-07-01" @default.
• W1526353609 modified "2023-09-23" @default.
• W1526353609 title "Molecular Roots of Degenerate Specificity in Syntenin's PDZ2 Domain" @default.
• W1526353609 cites W1534406877 @default.
• W1526353609 cites W1755064335 @default.
• W1526353609 cites W1890918162 @default.
• W1526353609 cites W1974322337 @default.
• W1526353609 cites W1985169370 @default.
• W1526353609 cites W1987704449 @default.
• W1526353609 cites W1988594478 @default.
• W1526353609 cites W1989038231 @default.
• W1526353609 cites W1993238323 @default.
• W1526353609 cites W1995691453 @default.
• W1526353609 cites W1996320892 @default.
• W1526353609 cites W2008951017 @default.
• W1526353609 cites W2012181614 @default.
• W1526353609 cites W2013083986 @default.
• W1526353609 cites W2013623015 @default.
• W1526353609 cites W2017273324 @default.
• W1526353609 cites W2025378142 @default.
• W1526353609 cites W2028231353 @default.
• W1526353609 cites W2029815031 @default.
• W1526353609 cites W2038840577 @default.
• W1526353609 cites W2048183896 @default.
• W1526353609 cites W2063216482 @default.
• W1526353609 cites W2064258134 @default.
• W1526353609 cites W2065989745 @default.
• W1526353609 cites W2071430620 @default.
• W1526353609 cites W2073355679 @default.
• W1526353609 cites W2075308337 @default.
• W1526353609 cites W2076225536 @default.
• W1526353609 cites W2076639450 @default.
• W1526353609 cites W2080476827 @default.
• W1526353609 cites W2080711919 @default.
• W1526353609 cites W2085865633 @default.
• W1526353609 cites W2093551073 @default.
• W1526353609 cites W2105006060 @default.
• W1526353609 cites W2115050780 @default.
• W1526353609 cites W2138528192 @default.
• W1526353609 cites W2156999424 @default.
• W1526353609 cites W2160260982 @default.
• W1526353609 cites W2171263596 @default.
• W1526353609 cites W96938930 @default.
• W1526353609 doi "https://doi.org/10.1016/s0969-2126(03)00125-4" @default.
• W1526353609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842047" @default.
• W1526353609 hasPublicationYear "2003" @default.
• W1526353609 type Work @default.
• W1526353609 sameAs 1526353609 @default.
• W1526353609 citedByCount "80" @default.
• W1526353609 countsByYear W15263536092012 @default.
• W1526353609 countsByYear W15263536092013 @default.
• W1526353609 countsByYear W15263536092014 @default.
• W1526353609 countsByYear W15263536092016 @default.
• W1526353609 countsByYear W15263536092018 @default.
• W1526353609 countsByYear W15263536092019 @default.
• W1526353609 countsByYear W15263536092020 @default.
• W1526353609 countsByYear W15263536092021 @default.
• W1526353609 countsByYear W15263536092023 @default.
• W1526353609 crossrefType "journal-article" @default.
• W1526353609 hasAuthorship W1526353609A5038550661 @default.
• W1526353609 hasAuthorship W1526353609A5042893936 @default.
• W1526353609 hasAuthorship W1526353609A5055855625 @default.
• W1526353609 hasAuthorship W1526353609A5080893332 @default.
• W1526353609 hasAuthorship W1526353609A5090502997 @default.
• W1526353609 hasBestOaLocation W15263536091 @default.
• W1526353609 hasConcept C107824862 @default.
• W1526353609 hasConcept C121332964 @default.
• W1526353609 hasConcept C134306372 @default.
• W1526353609 hasConcept C14036430 @default.
• W1526353609 hasConcept C1491633281 @default.
• W1526353609 hasConcept C154428179 @default.
• W1526353609 hasConcept C185592680 @default.
• W1526353609 hasConcept C2780283098 @default.
• W1526353609 hasConcept C33923547 @default.
• W1526353609 hasConcept C36503486 @default.
• W1526353609 hasConcept C55493867 @default.
• W1526353609 hasConcept C62520636 @default.
• W1526353609 hasConcept C65001120 @default.
• W1526353609 hasConcept C70721500 @default.
• W1526353609 hasConcept C71240020 @default.
• W1526353609 hasConcept C72319582 @default.
• W1526353609 hasConcept C8010536 @default.
• W1526353609 hasConcept C86803240 @default.
• W1526353609 hasConcept C95444343 @default.
• W1526353609 hasConceptScore W1526353609C107824862 @default.
• W1526353609 hasConceptScore W1526353609C121332964 @default.
• W1526353609 hasConceptScore W1526353609C134306372 @default.
• W1526353609 hasConceptScore W1526353609C14036430 @default.
• W1526353609 hasConceptScore W1526353609C1491633281 @default.
• W1526353609 hasConceptScore W1526353609C154428179 @default.
• W1526353609 hasConceptScore W1526353609C185592680 @default.

• next