FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526492968> ?p ?o ?g. }

• W1526492968 endingPage "329" @default.
• W1526492968 startingPage "325" @default.
• W1526492968 abstract "Background and Aim Fasudil, a Rho-kinase inhibitor, has been shown to reduce portal venous pressure in cirrhotic rats. However, its effects on portal and systemic hemodynamics have not been investigated in cirrhotic patients with portal hypertension. The aim of this study was to assess the effects of fasudil on the portal and systemic hemodynamics of cirrhotic patients with portal hypertension. Methods Twenty-three patients with cirrhosis and portal hypertension were studied. Systemic and portal hemodynamics were measured prior to and 50 min after the initiation of intravenous administration of 30 mg fasudil (n = 15) or placebo (n = 8). Results After fasudil, there were significant decreases in both mean arterial pressure (P < 0.05) and systemic vascular resistance (P < 0.05), whereas the heart rate increased significantly (P < 0.05). There was a significant decrease in the hepatic venous pressure gradient (P < 0.05). Portal vascular resistance also decreased significantly (P < 0.01). Placebo caused no significant effects. There were no symptomatic reactions caused by changes in the mean arterial pressure or heart rate after fasudil. Conclusions In cirrhotic patients with portal hypertension, fasudil lowers portal vascular resistance, resulting in decreased portal venous pressure with reducing arterial pressure." @default.
• W1526492968 created "2016-06-24" @default.
• W1526492968 creator A5000519458 @default.
• W1526492968 creator A5001196940 @default.
• W1526492968 creator A5009103376 @default.
• W1526492968 creator A5024021161 @default.
• W1526492968 creator A5033986386 @default.
• W1526492968 creator A5039999047 @default.
• W1526492968 creator A5067992625 @default.
• W1526492968 creator A5071884163 @default.
• W1526492968 creator A5073807260 @default.
• W1526492968 creator A5080709934 @default.
• W1526492968 date "2014-01-27" @default.
• W1526492968 modified "2023-10-16" @default.
• W1526492968 title "Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis" @default.
• W1526492968 cites W1597787921 @default.
• W1526492968 cites W1803783718 @default.
• W1526492968 cites W1902300865 @default.
• W1526492968 cites W1963673927 @default.
• W1526492968 cites W1977983569 @default.
• W1526492968 cites W1980165146 @default.
• W1526492968 cites W2000755848 @default.
• W1526492968 cites W2016955748 @default.
• W1526492968 cites W2019731805 @default.
• W1526492968 cites W2025189929 @default.
• W1526492968 cites W2051944167 @default.
• W1526492968 cites W2062818431 @default.
• W1526492968 cites W2066542029 @default.
• W1526492968 cites W2075126241 @default.
• W1526492968 cites W2102180587 @default.
• W1526492968 cites W2108116605 @default.
• W1526492968 cites W2108195516 @default.
• W1526492968 cites W2111651135 @default.
• W1526492968 cites W2130406955 @default.
• W1526492968 cites W2141632000 @default.
• W1526492968 cites W2146615847 @default.
• W1526492968 cites W2161467739 @default.
• W1526492968 cites W2170155226 @default.
• W1526492968 cites W2171943778 @default.
• W1526492968 doi "https://doi.org/10.1111/jgh.12360" @default.
• W1526492968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24033356" @default.
• W1526492968 hasPublicationYear "2014" @default.
• W1526492968 type Work @default.
• W1526492968 sameAs 1526492968 @default.
• W1526492968 citedByCount "16" @default.
• W1526492968 countsByYear W15264929682015 @default.
• W1526492968 countsByYear W15264929682016 @default.
• W1526492968 countsByYear W15264929682018 @default.
• W1526492968 countsByYear W15264929682020 @default.
• W1526492968 countsByYear W15264929682021 @default.
• W1526492968 countsByYear W15264929682022 @default.
• W1526492968 countsByYear W15264929682023 @default.
• W1526492968 crossrefType "journal-article" @default.
• W1526492968 hasAuthorship W1526492968A5000519458 @default.
• W1526492968 hasAuthorship W1526492968A5001196940 @default.
• W1526492968 hasAuthorship W1526492968A5009103376 @default.
• W1526492968 hasAuthorship W1526492968A5024021161 @default.
• W1526492968 hasAuthorship W1526492968A5033986386 @default.
• W1526492968 hasAuthorship W1526492968A5039999047 @default.
• W1526492968 hasAuthorship W1526492968A5067992625 @default.
• W1526492968 hasAuthorship W1526492968A5071884163 @default.
• W1526492968 hasAuthorship W1526492968A5073807260 @default.
• W1526492968 hasAuthorship W1526492968A5080709934 @default.
• W1526492968 hasConcept C126322002 @default.
• W1526492968 hasConcept C164705383 @default.
• W1526492968 hasConcept C178853913 @default.
• W1526492968 hasConcept C185592680 @default.
• W1526492968 hasConcept C201800478 @default.
• W1526492968 hasConcept C2776048814 @default.
• W1526492968 hasConcept C2777214474 @default.
• W1526492968 hasConcept C2778808290 @default.
• W1526492968 hasConcept C55493867 @default.
• W1526492968 hasConcept C56900294 @default.
• W1526492968 hasConcept C58245268 @default.
• W1526492968 hasConcept C62478195 @default.
• W1526492968 hasConcept C71924100 @default.
• W1526492968 hasConcept C84393581 @default.
• W1526492968 hasConceptScore W1526492968C126322002 @default.
• W1526492968 hasConceptScore W1526492968C164705383 @default.
• W1526492968 hasConceptScore W1526492968C178853913 @default.
• W1526492968 hasConceptScore W1526492968C185592680 @default.
• W1526492968 hasConceptScore W1526492968C201800478 @default.
• W1526492968 hasConceptScore W1526492968C2776048814 @default.
• W1526492968 hasConceptScore W1526492968C2777214474 @default.
• W1526492968 hasConceptScore W1526492968C2778808290 @default.
• W1526492968 hasConceptScore W1526492968C55493867 @default.
• W1526492968 hasConceptScore W1526492968C56900294 @default.
• W1526492968 hasConceptScore W1526492968C58245268 @default.
• W1526492968 hasConceptScore W1526492968C62478195 @default.
• W1526492968 hasConceptScore W1526492968C71924100 @default.
• W1526492968 hasConceptScore W1526492968C84393581 @default.
• W1526492968 hasIssue "2" @default.
• W1526492968 hasLocation W15264929681 @default.
• W1526492968 hasLocation W15264929682 @default.
• W1526492968 hasOpenAccess W1526492968 @default.
• W1526492968 hasPrimaryLocation W15264929681 @default.
• W1526492968 hasRelatedWork W1526492968 @default.
• W1526492968 hasRelatedWork W1973972854 @default.

• next