Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526493867> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1526493867 endingPage "64" @default.
- W1526493867 startingPage "3158" @default.
- W1526493867 abstract "The in vivo and in vitro antitumor effectiveness of IFNs is well documented. Their combination with differentiating agents, such as retinoic acid, has been demonstrated to be a promising therapy for patients with advanced squamous cell cancer of the skin and the cervix. However, the mechanisms that mediate these antitumor responses are not yet known. We studied the epidermoid cell line ME 180 derived from human cervical carcinoma to test its responsiveness to IFN-alpha-2b (INTRON A) and all-trans-retinoic acid (RA). Both agents have demonstrated ability to inhibit the growth of ME 180 cells in a dose- and time-dependent manner. The antiproliferative effect was further increased by the treatment with IFN-alpha-2b and RA combined. In accordance with this result, we found that the combination of the two agents has the effect of increasing the expression of the 2-5A synthetase gene, which is thought to play a key role in antigrowth responses to IFNs. At increased levels of 2-5A synthetase mRNA corresponds a significant increase in 2-5A synthetase activity. Although RA per se has no effect on the 2-5A synthetase expression, when it is combined with IFN-alpha-2b it appears to be able to potentiate the IFN-induced 2-5A synthetase expression. Moreover, the combination of IFN-alpha-2b and RA produces a similar effect also on the expression of the HLA-A2 gene, which has been shown to be induced in ME 180 cells both by IFN-alpha-2b and RA alone. In view of the possible mechanisms of action of the two agents, it is interesting to note that their combination increases, although transiently, the expression of IRF1, which codes for a transcription factor that regulates IFN gene expression and is thought to be involved in the regulation of IFN-induced effects and in mediating cell death or apoptosis." @default.
- W1526493867 created "2016-06-24" @default.
- W1526493867 creator A5014072320 @default.
- W1526493867 creator A5021764629 @default.
- W1526493867 creator A5040913442 @default.
- W1526493867 creator A5055505091 @default.
- W1526493867 creator A5081435652 @default.
- W1526493867 creator A5087874445 @default.
- W1526493867 date "1995-07-15" @default.
- W1526493867 modified "2023-09-23" @default.
- W1526493867 title "Interferon alpha-2b and retinoic acid combined treatment affects proliferation and gene expression of human cervical carcinoma cells." @default.
- W1526493867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7606736" @default.
- W1526493867 hasPublicationYear "1995" @default.
- W1526493867 type Work @default.
- W1526493867 sameAs 1526493867 @default.
- W1526493867 citedByCount "20" @default.
- W1526493867 countsByYear W15264938672015 @default.
- W1526493867 crossrefType "journal-article" @default.
- W1526493867 hasAuthorship W1526493867A5014072320 @default.
- W1526493867 hasAuthorship W1526493867A5021764629 @default.
- W1526493867 hasAuthorship W1526493867A5040913442 @default.
- W1526493867 hasAuthorship W1526493867A5055505091 @default.
- W1526493867 hasAuthorship W1526493867A5081435652 @default.
- W1526493867 hasAuthorship W1526493867A5087874445 @default.
- W1526493867 hasConcept C104317684 @default.
- W1526493867 hasConcept C150194340 @default.
- W1526493867 hasConcept C153911025 @default.
- W1526493867 hasConcept C159110408 @default.
- W1526493867 hasConcept C202751555 @default.
- W1526493867 hasConcept C203014093 @default.
- W1526493867 hasConcept C207001950 @default.
- W1526493867 hasConcept C2775944032 @default.
- W1526493867 hasConcept C2776178377 @default.
- W1526493867 hasConcept C2781121885 @default.
- W1526493867 hasConcept C2909179924 @default.
- W1526493867 hasConcept C49453240 @default.
- W1526493867 hasConcept C502942594 @default.
- W1526493867 hasConcept C54355233 @default.
- W1526493867 hasConcept C55493867 @default.
- W1526493867 hasConcept C64943373 @default.
- W1526493867 hasConcept C71924100 @default.
- W1526493867 hasConcept C81885089 @default.
- W1526493867 hasConcept C86803240 @default.
- W1526493867 hasConceptScore W1526493867C104317684 @default.
- W1526493867 hasConceptScore W1526493867C150194340 @default.
- W1526493867 hasConceptScore W1526493867C153911025 @default.
- W1526493867 hasConceptScore W1526493867C159110408 @default.
- W1526493867 hasConceptScore W1526493867C202751555 @default.
- W1526493867 hasConceptScore W1526493867C203014093 @default.
- W1526493867 hasConceptScore W1526493867C207001950 @default.
- W1526493867 hasConceptScore W1526493867C2775944032 @default.
- W1526493867 hasConceptScore W1526493867C2776178377 @default.
- W1526493867 hasConceptScore W1526493867C2781121885 @default.
- W1526493867 hasConceptScore W1526493867C2909179924 @default.
- W1526493867 hasConceptScore W1526493867C49453240 @default.
- W1526493867 hasConceptScore W1526493867C502942594 @default.
- W1526493867 hasConceptScore W1526493867C54355233 @default.
- W1526493867 hasConceptScore W1526493867C55493867 @default.
- W1526493867 hasConceptScore W1526493867C64943373 @default.
- W1526493867 hasConceptScore W1526493867C71924100 @default.
- W1526493867 hasConceptScore W1526493867C81885089 @default.
- W1526493867 hasConceptScore W1526493867C86803240 @default.
- W1526493867 hasIssue "14" @default.
- W1526493867 hasLocation W15264938671 @default.
- W1526493867 hasOpenAccess W1526493867 @default.
- W1526493867 hasPrimaryLocation W15264938671 @default.
- W1526493867 hasRelatedWork W1829715263 @default.
- W1526493867 hasRelatedWork W2020692772 @default.
- W1526493867 hasRelatedWork W2022380573 @default.
- W1526493867 hasRelatedWork W2037587316 @default.
- W1526493867 hasRelatedWork W2049839328 @default.
- W1526493867 hasRelatedWork W2063932055 @default.
- W1526493867 hasRelatedWork W2073585346 @default.
- W1526493867 hasRelatedWork W2088233396 @default.
- W1526493867 hasRelatedWork W2325718104 @default.
- W1526493867 hasRelatedWork W2470168644 @default.
- W1526493867 hasVolume "55" @default.
- W1526493867 isParatext "false" @default.
- W1526493867 isRetracted "false" @default.
- W1526493867 magId "1526493867" @default.
- W1526493867 workType "article" @default.