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- W152649905 abstract "Cilia establish the vertebrate left-right (LR) axis and are integral to the development and function of the kidney, liver, and brain. Left-right asymmetry is established in the ciliated ventral node cells of the mouse. The chiral structure of the cilium provides a reference asymmetry to impose handed LR asymmetric development on the bilaterally symmetric vertebrate embryo. A ciliary mechanism of LR development is evolutionarily conserved, as ciliated organs essential to LR axis formation, called LR organizers, are found in other vertebrates, including rabbit, fish, and Xenopus. Mice with mutations affecting ciliary biogenesis, motility, or sensory function have abnormal LR development and abnormal development of the heart. The axonemal dynein heavy chain left-right dynein (lrd) localizes to the LR organizer and drives counterclockwise movement of node primary cilia. Node primary cilia are an admixture of 9 + 2 and 9 + 0 cilia. Mutations in lrd result in structurally normal, immotile node monocilia. In the mouse, coordinated, directional beating of motile node monocilia at the neural fold stage generates leftward flow of extraembryonic fluid surrounding the node (nodal flow). Nodal flow triggers a rise in intracellular calcium in cells at the left side of the node. The perinodal asymmetric rise in intracellular calcium generated by nodal flow subsequently leads to asymmetric gene expression and morphogenesis." @default.
- W152649905 created "2016-06-24" @default.
- W152649905 creator A5002562071 @default.
- W152649905 creator A5044488529 @default.
- W152649905 date "2008-01-01" @default.
- W152649905 modified "2023-09-23" @default.
- W152649905 title "Cilia multifunctional organelles at the center of vertebrate left-right asymmetry." @default.
- W152649905 cites W107262396 @default.
- W152649905 cites W1486556201 @default.
- W152649905 cites W1677326748 @default.
- W152649905 cites W1693754698 @default.
- W152649905 cites W1783360620 @default.
- W152649905 cites W1784820495 @default.
- W152649905 cites W1871182286 @default.
- W152649905 cites W1897871655 @default.
- W152649905 cites W190264466 @default.
- W152649905 cites W1911359980 @default.
- W152649905 cites W1962669878 @default.
- W152649905 cites W1965813423 @default.
- W152649905 cites W1967146176 @default.
- W152649905 cites W1967546149 @default.
- W152649905 cites W1969212379 @default.
- W152649905 cites W1970264904 @default.
- W152649905 cites W1972801661 @default.
- W152649905 cites W1978969746 @default.
- W152649905 cites W1980398966 @default.
- W152649905 cites W1980747541 @default.
- W152649905 cites W1982118621 @default.
- W152649905 cites W1982168739 @default.
- W152649905 cites W1983538981 @default.
- W152649905 cites W1985117787 @default.
- W152649905 cites W1987279648 @default.
- W152649905 cites W1988977149 @default.
- W152649905 cites W1989155678 @default.
- W152649905 cites W1990888292 @default.
- W152649905 cites W1991454115 @default.
- W152649905 cites W1995542274 @default.
- W152649905 cites W1998189290 @default.
- W152649905 cites W2000791177 @default.
- W152649905 cites W2003103160 @default.
- W152649905 cites W2004559089 @default.
- W152649905 cites W2011630484 @default.
- W152649905 cites W2011697505 @default.
- W152649905 cites W2018752667 @default.
- W152649905 cites W2028607959 @default.
- W152649905 cites W2029279705 @default.
- W152649905 cites W2031411430 @default.
- W152649905 cites W2033799985 @default.
- W152649905 cites W2039582989 @default.
- W152649905 cites W2041119049 @default.
- W152649905 cites W2043072715 @default.
- W152649905 cites W2046039219 @default.
- W152649905 cites W2047837497 @default.
- W152649905 cites W2049365982 @default.
- W152649905 cites W2056824123 @default.
- W152649905 cites W2058050622 @default.
- W152649905 cites W2058525645 @default.
- W152649905 cites W2064659330 @default.
- W152649905 cites W2067354658 @default.
- W152649905 cites W2068762378 @default.
- W152649905 cites W2069014283 @default.
- W152649905 cites W2073174918 @default.
- W152649905 cites W2074504350 @default.
- W152649905 cites W2077557886 @default.
- W152649905 cites W2078083753 @default.
- W152649905 cites W2083904901 @default.
- W152649905 cites W2084105838 @default.
- W152649905 cites W2084412673 @default.
- W152649905 cites W2089781848 @default.
- W152649905 cites W2091684557 @default.
- W152649905 cites W2092178332 @default.
- W152649905 cites W2092778272 @default.
- W152649905 cites W2094442354 @default.
- W152649905 cites W2097822173 @default.
- W152649905 cites W2102864788 @default.
- W152649905 cites W2104158696 @default.
- W152649905 cites W2105652702 @default.
- W152649905 cites W2110004228 @default.
- W152649905 cites W2110894673 @default.
- W152649905 cites W2112331825 @default.
- W152649905 cites W2118597315 @default.
- W152649905 cites W2120410199 @default.
- W152649905 cites W2120982579 @default.
- W152649905 cites W2122596916 @default.
- W152649905 cites W2125720034 @default.
- W152649905 cites W2126624378 @default.
- W152649905 cites W2129794832 @default.
- W152649905 cites W2130786979 @default.
- W152649905 cites W2141231399 @default.
- W152649905 cites W2141313696 @default.
- W152649905 cites W2145173438 @default.
- W152649905 cites W2149312421 @default.
- W152649905 cites W2152931318 @default.
- W152649905 cites W2155876603 @default.
- W152649905 cites W2159407840 @default.
- W152649905 cites W2160084509 @default.
- W152649905 cites W2161821489 @default.
- W152649905 cites W2167735959 @default.