FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526832384> ?p ?o ?g. }

• W1526832384 endingPage "8451" @default.
• W1526832384 startingPage "8442" @default.
• W1526832384 abstract "// Frank Eckerdt 1 , Elspeth Beauchamp 1,2 , Jonathan Bell 1 , Asneha Iqbal 1,3 , Bing Su 4,5 , Rikiro Fukunaga 6 , Rishi R. Lulla 1,3 , Stewart Goldman 1,3 and Leonidas C. Platanias 1, 2 1 Robert H. Lurie Comprehensive Cancer Center and Division of Hematology- Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL,USA 2 Department of Medicine, Jesse Brown VA Medical Center, Chicago, IL, USA 3 Division of Hematology and Oncology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA 4 Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA 5 Shanghai Institute of Immunology Department of Microbiology and Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China 6 Laboratory of Biochemistry, Osaka University of Pharmaceutical Sciences, Osaka, Japan Correspondence: Leonidas C. Platanias, email: // Keywords : TOR, Mnk, rapamycin, medulloblastoma Received : June 26, 2014 Accepted : August 05, 2014 Published : August 06, 2014 Abstract The mTOR pathway controls mRNA translation of mitogenic proteins and is a central regulator of metabolism in malignant cells. Development of malignant cell resistance is a limiting factor to the effects of mTOR inhibitors, but the mechanisms accounting for such resistance are not well understood. We provide evidence that mTORC1 inhibition by rapamycin results in engagement of a negative feedback regulatory loop in malignant medulloblastoma cells, involving phosphorylation of the eukaryotic translation-initiation factor eIF4E. This eIF4E phosphorylation is Mnk2- mediated, but Mnk1-independent, and acts as a survival mechanism for medulloblastoma cells. Pharmacological targeting of Mnk1/2 or siRNA-mediated knockdown of Mnk2 sensitizes medulloblastoma cells to mTOR inhibition and promotes suppression of malignant cell proliferation and anchorage-independent growth. Altogether, these findings provide evidence for the existence of a Mnk2-controlled feedback loop in medulloblastoma cells that accounts for resistance to mTOR inhibitors, and raise the potential for combination treatments of mTOR and Mnk inhibitors for the treatment of medulloblastoma." @default.
• W1526832384 created "2016-06-24" @default.
• W1526832384 creator A5024756660 @default.
• W1526832384 creator A5036617904 @default.
• W1526832384 creator A5039821839 @default.
• W1526832384 creator A5045973913 @default.
• W1526832384 creator A5051335860 @default.
• W1526832384 creator A5071378074 @default.
• W1526832384 creator A5076426894 @default.
• W1526832384 creator A5077679072 @default.
• W1526832384 creator A5078403556 @default.
• W1526832384 date "2014-08-06" @default.
• W1526832384 modified "2023-10-18" @default.
• W1526832384 title "Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells" @default.
• W1526832384 cites W1964675052 @default.
• W1526832384 cites W1974625077 @default.
• W1526832384 cites W1979855662 @default.
• W1526832384 cites W1986781282 @default.
• W1526832384 cites W1989773068 @default.
• W1526832384 cites W2005234434 @default.
• W1526832384 cites W2013075901 @default.
• W1526832384 cites W2015514843 @default.
• W1526832384 cites W2017018900 @default.
• W1526832384 cites W2022266045 @default.
• W1526832384 cites W2029348880 @default.
• W1526832384 cites W2032666422 @default.
• W1526832384 cites W2039379153 @default.
• W1526832384 cites W2044411751 @default.
• W1526832384 cites W2052117124 @default.
• W1526832384 cites W2062575689 @default.
• W1526832384 cites W2078844752 @default.
• W1526832384 cites W2080451230 @default.
• W1526832384 cites W2089020035 @default.
• W1526832384 cites W2089716875 @default.
• W1526832384 cites W2094467762 @default.
• W1526832384 cites W2102148658 @default.
• W1526832384 cites W2102889876 @default.
• W1526832384 cites W2109387038 @default.
• W1526832384 cites W2113491029 @default.
• W1526832384 cites W2117028091 @default.
• W1526832384 cites W2121647526 @default.
• W1526832384 cites W2127329372 @default.
• W1526832384 cites W2132048053 @default.
• W1526832384 cites W2132519593 @default.
• W1526832384 cites W2146854566 @default.
• W1526832384 cites W2148915086 @default.
• W1526832384 cites W2150595264 @default.
• W1526832384 cites W2152589884 @default.
• W1526832384 cites W2167532631 @default.
• W1526832384 cites W2167680876 @default.
• W1526832384 cites W4238567307 @default.
• W1526832384 doi "https://doi.org/10.18632/oncotarget.2319" @default.
• W1526832384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4226695" @default.
• W1526832384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25193863" @default.
• W1526832384 hasPublicationYear "2014" @default.
• W1526832384 type Work @default.
• W1526832384 sameAs 1526832384 @default.
• W1526832384 citedByCount "36" @default.
• W1526832384 countsByYear W15268323842015 @default.
• W1526832384 countsByYear W15268323842016 @default.
• W1526832384 countsByYear W15268323842017 @default.
• W1526832384 countsByYear W15268323842018 @default.
• W1526832384 countsByYear W15268323842019 @default.
• W1526832384 countsByYear W15268323842020 @default.
• W1526832384 countsByYear W15268323842021 @default.
• W1526832384 countsByYear W15268323842023 @default.
• W1526832384 crossrefType "journal-article" @default.
• W1526832384 hasAuthorship W1526832384A5024756660 @default.
• W1526832384 hasAuthorship W1526832384A5036617904 @default.
• W1526832384 hasAuthorship W1526832384A5039821839 @default.
• W1526832384 hasAuthorship W1526832384A5045973913 @default.
• W1526832384 hasAuthorship W1526832384A5051335860 @default.
• W1526832384 hasAuthorship W1526832384A5071378074 @default.
• W1526832384 hasAuthorship W1526832384A5076426894 @default.
• W1526832384 hasAuthorship W1526832384A5077679072 @default.
• W1526832384 hasAuthorship W1526832384A5078403556 @default.
• W1526832384 hasBestOaLocation W15268323841 @default.
• W1526832384 hasConcept C104317684 @default.
• W1526832384 hasConcept C105580179 @default.
• W1526832384 hasConcept C126322002 @default.
• W1526832384 hasConcept C143998085 @default.
• W1526832384 hasConcept C149364088 @default.
• W1526832384 hasConcept C161295673 @default.
• W1526832384 hasConcept C173396325 @default.
• W1526832384 hasConcept C194409129 @default.
• W1526832384 hasConcept C2777949483 @default.
• W1526832384 hasConcept C2780789225 @default.
• W1526832384 hasConcept C502942594 @default.
• W1526832384 hasConcept C54355233 @default.
• W1526832384 hasConcept C62478195 @default.
• W1526832384 hasConcept C71924100 @default.
• W1526832384 hasConcept C81885089 @default.
• W1526832384 hasConcept C86554907 @default.
• W1526832384 hasConcept C86803240 @default.
• W1526832384 hasConcept C98490376 @default.
• W1526832384 hasConceptScore W1526832384C104317684 @default.
• W1526832384 hasConceptScore W1526832384C105580179 @default.
• W1526832384 hasConceptScore W1526832384C126322002 @default.

• next