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- W1526834337 abstract "Considerable research has been conducted on mitochondrial biology as it pertains to aging. However, relatively little attention has been accorded the pyruvate dehydrogenase complex (PDC) relative to how we grow old and acquire age-related diseases. The purpose of this review is threefold: first, to describe the physiological chemistry of the PDC and define its place in normal cellular bioenergetics; second, to compare and contrast the pathogenesis and clinical features of congenital PDC deficiency with discrete examples of age-associated dysfunction of the complex; and third, to summarize recent findings in Caenorhabditis elegans that shed additional new light on the significance of the PDC to the aging process." @default.
- W1526834337 created "2016-06-24" @default.
- W1526834337 creator A5080489320 @default.
- W1526834337 date "2012-04-04" @default.
- W1526834337 modified "2023-09-30" @default.
- W1526834337 title "The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases" @default.
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- W1526834337 doi "https://doi.org/10.1111/j.1474-9726.2012.00805.x" @default.
- W1526834337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22321732" @default.
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