FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1526978170> ?p ?o ?g. }

• W1526978170 endingPage "2652" @default.
• W1526978170 startingPage "2646" @default.
• W1526978170 abstract "Following the differentiation of 3T3-L1 preadipocytes insulin acutely activates the rate of 2-deoxy-[1-14C]glucose uptake in the mature 3T3-L1 adipocyte by 15- to 20-fold. Phenylarsine oxide, a trivalent arsenical that forms stable ring complexes with vicinal dithiols, prevents insulin-activated hexose uptake in a concentration-dependent manner (Ki = 7 microM) but has no inhibitory effect on basal hexose uptake. 2,3-Dimercaptopropanol at a level nearly stoichiometric to that of phenylarsine oxide prevents or rapidly reverses the inhibition of hexose uptake; 2-mercaptoethanol, even in high stoichiometric excess over the arsenical, does not reverse inhibition of hexose uptake. When phenylarsine oxide is added after adipocytes have been fully activated by insulin, 2-deoxy-[1-14C]glucose uptake rate decays slowly at a rate corresponding to that caused by the withdrawal of insulin (t1/2 = 10 min). Using the same conditions under which phenylarsine oxide blocked activation, the Km for deoxyglucose uptake, the rate at which 125I-insulin became cell-associated, and the 125I-insulin binding isotherm for solubilized insulin receptor were not affected by phenylarsine oxide. These results support the transporter translocation model for insulin-activated hexose transport and implicate vicinal sulfhydryl groups in a post-insulin binding event essential for the translocation of glucose transporters to the plasma membrane." @default.
• W1526978170 created "2016-06-24" @default.
• W1526978170 creator A5004441263 @default.
• W1526978170 creator A5012475457 @default.
• W1526978170 date "1985-03-01" @default.
• W1526978170 modified "2023-10-14" @default.
• W1526978170 title "Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes." @default.
• W1526978170 cites W1013523815 @default.
• W1526978170 cites W1491339323 @default.
• W1526978170 cites W1531108159 @default.
• W1526978170 cites W1560434293 @default.
• W1526978170 cites W1561326814 @default.
• W1526978170 cites W1573547824 @default.
• W1526978170 cites W1575266405 @default.
• W1526978170 cites W1576268619 @default.
• W1526978170 cites W1579899042 @default.
• W1526978170 cites W1587165109 @default.
• W1526978170 cites W164548000 @default.
• W1526978170 cites W1847726157 @default.
• W1526978170 cites W2001736800 @default.
• W1526978170 cites W2005322770 @default.
• W1526978170 cites W2042194183 @default.
• W1526978170 cites W2042414962 @default.
• W1526978170 cites W2044591753 @default.
• W1526978170 cites W2049130156 @default.
• W1526978170 cites W2055346353 @default.
• W1526978170 cites W2070892348 @default.
• W1526978170 cites W2171274730 @default.
• W1526978170 cites W2185111276 @default.
• W1526978170 cites W334182481 @default.
• W1526978170 cites W37050816 @default.
• W1526978170 cites W4251494161 @default.
• W1526978170 cites W88023215 @default.
• W1526978170 doi "https://doi.org/10.1016/s0021-9258(18)89409-1" @default.
• W1526978170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3882699" @default.
• W1526978170 hasPublicationYear "1985" @default.
• W1526978170 type Work @default.
• W1526978170 sameAs 1526978170 @default.
• W1526978170 citedByCount "497" @default.
• W1526978170 countsByYear W15269781702012 @default.
• W1526978170 countsByYear W15269781702013 @default.
• W1526978170 countsByYear W15269781702014 @default.
• W1526978170 countsByYear W15269781702015 @default.
• W1526978170 countsByYear W15269781702016 @default.
• W1526978170 countsByYear W15269781702017 @default.
• W1526978170 countsByYear W15269781702018 @default.
• W1526978170 countsByYear W15269781702019 @default.
• W1526978170 countsByYear W15269781702020 @default.
• W1526978170 countsByYear W15269781702021 @default.
• W1526978170 countsByYear W15269781702022 @default.
• W1526978170 crossrefType "journal-article" @default.
• W1526978170 hasAuthorship W1526978170A5004441263 @default.
• W1526978170 hasAuthorship W1526978170A5012475457 @default.
• W1526978170 hasBestOaLocation W15269781701 @default.
• W1526978170 hasConcept C121349320 @default.
• W1526978170 hasConcept C126322002 @default.
• W1526978170 hasConcept C134018914 @default.
• W1526978170 hasConcept C142536801 @default.
• W1526978170 hasConcept C171089720 @default.
• W1526978170 hasConcept C178790620 @default.
• W1526978170 hasConcept C181199279 @default.
• W1526978170 hasConcept C185592680 @default.
• W1526978170 hasConcept C2776175234 @default.
• W1526978170 hasConcept C2776393687 @default.
• W1526978170 hasConcept C2777866211 @default.
• W1526978170 hasConcept C2779306644 @default.
• W1526978170 hasConcept C55493867 @default.
• W1526978170 hasConcept C71924100 @default.
• W1526978170 hasConcept C86803240 @default.
• W1526978170 hasConceptScore W1526978170C121349320 @default.
• W1526978170 hasConceptScore W1526978170C126322002 @default.
• W1526978170 hasConceptScore W1526978170C134018914 @default.
• W1526978170 hasConceptScore W1526978170C142536801 @default.
• W1526978170 hasConceptScore W1526978170C171089720 @default.
• W1526978170 hasConceptScore W1526978170C178790620 @default.
• W1526978170 hasConceptScore W1526978170C181199279 @default.
• W1526978170 hasConceptScore W1526978170C185592680 @default.
• W1526978170 hasConceptScore W1526978170C2776175234 @default.
• W1526978170 hasConceptScore W1526978170C2776393687 @default.
• W1526978170 hasConceptScore W1526978170C2777866211 @default.
• W1526978170 hasConceptScore W1526978170C2779306644 @default.
• W1526978170 hasConceptScore W1526978170C55493867 @default.
• W1526978170 hasConceptScore W1526978170C71924100 @default.
• W1526978170 hasConceptScore W1526978170C86803240 @default.
• W1526978170 hasIssue "5" @default.
• W1526978170 hasLocation W15269781701 @default.
• W1526978170 hasOpenAccess W1526978170 @default.
• W1526978170 hasPrimaryLocation W15269781701 @default.
• W1526978170 hasRelatedWork W1966660296 @default.
• W1526978170 hasRelatedWork W2006513370 @default.
• W1526978170 hasRelatedWork W2007347894 @default.
• W1526978170 hasRelatedWork W2146199520 @default.
• W1526978170 hasRelatedWork W2155949848 @default.
• W1526978170 hasRelatedWork W2158888587 @default.
• W1526978170 hasRelatedWork W2180861891 @default.
• W1526978170 hasRelatedWork W2186867184 @default.
• W1526978170 hasRelatedWork W2398044546 @default.
• W1526978170 hasRelatedWork W2415319372 @default.

• next