Matches in SemOpenAlex for { <https://semopenalex.org/work/W1527103851> ?p ?o ?g. }
- W1527103851 endingPage "97" @default.
- W1527103851 startingPage "189" @default.
- W1527103851 abstract "We review how studies on the first Spemann-Mangold organizer marker, the homeobox gene goosecoid, led to the discovery of secreted factors that pattern the vertebrate embryo. Microinjection of goosecoid mRNA formed secondary axes and recruited neighboring cells. These non-cell autonomous effects are mediated in part by the expression of secreted factors such as chordin, cerberus and Frzb-1. Unexpectedly, many of the molecules secreted by the Spemann-Mangold organizer turned out to be antagonists that bind growth factors in the extracellular space and prevent them from binding to their receptors. The case of chordin is reviewed in detail, for this molecule has provided biochemical insights into how patterning by Spemann's organizer can be regulated by diffusion and proteolytic control. The study of the BMP-binding repeats of Chordin, which are present in many extracellular proteins, may provide a new paradigm for how cell-cell signaling is regulated in the extracellular space not only in embryos, but also in adult tissues." @default.
- W1527103851 created "2016-06-24" @default.
- W1527103851 creator A5000656708 @default.
- W1527103851 creator A5011623588 @default.
- W1527103851 creator A5011908254 @default.
- W1527103851 creator A5019782818 @default.
- W1527103851 creator A5037667875 @default.
- W1527103851 creator A5061518807 @default.
- W1527103851 creator A5066475986 @default.
- W1527103851 creator A5084946665 @default.
- W1527103851 date "2001-01-01" @default.
- W1527103851 modified "2023-09-27" @default.
- W1527103851 title "Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer." @default.
- W1527103851 cites W1495424955 @default.
- W1527103851 cites W1525122215 @default.
- W1527103851 cites W1554593075 @default.
- W1527103851 cites W1564357553 @default.
- W1527103851 cites W1582956895 @default.
- W1527103851 cites W1603468729 @default.
- W1527103851 cites W1657005131 @default.
- W1527103851 cites W1842953786 @default.
- W1527103851 cites W1870931504 @default.
- W1527103851 cites W1879493681 @default.
- W1527103851 cites W1888989725 @default.
- W1527103851 cites W1890787892 @default.
- W1527103851 cites W1902031853 @default.
- W1527103851 cites W1927171786 @default.
- W1527103851 cites W1930652382 @default.
- W1527103851 cites W1934065093 @default.
- W1527103851 cites W1968263279 @default.
- W1527103851 cites W1969910714 @default.
- W1527103851 cites W1969946661 @default.
- W1527103851 cites W1973134563 @default.
- W1527103851 cites W1974576894 @default.
- W1527103851 cites W1975996864 @default.
- W1527103851 cites W1982709013 @default.
- W1527103851 cites W1983653653 @default.
- W1527103851 cites W1984288177 @default.
- W1527103851 cites W1988350691 @default.
- W1527103851 cites W1990938412 @default.
- W1527103851 cites W1992134392 @default.
- W1527103851 cites W1998000268 @default.
- W1527103851 cites W1998342476 @default.
- W1527103851 cites W2002492576 @default.
- W1527103851 cites W2002549741 @default.
- W1527103851 cites W2011175428 @default.
- W1527103851 cites W2011205303 @default.
- W1527103851 cites W2014536457 @default.
- W1527103851 cites W2015892335 @default.
- W1527103851 cites W2025019677 @default.
- W1527103851 cites W2025853097 @default.
- W1527103851 cites W2028442510 @default.
- W1527103851 cites W2029482176 @default.
- W1527103851 cites W2033904138 @default.
- W1527103851 cites W2037408712 @default.
- W1527103851 cites W2042297889 @default.
- W1527103851 cites W2042859849 @default.
- W1527103851 cites W2044384686 @default.
- W1527103851 cites W2044615295 @default.
- W1527103851 cites W2045631728 @default.
- W1527103851 cites W2046597024 @default.
- W1527103851 cites W2047165320 @default.
- W1527103851 cites W2069598734 @default.
- W1527103851 cites W2070849620 @default.
- W1527103851 cites W2071135527 @default.
- W1527103851 cites W2074597244 @default.
- W1527103851 cites W2079406338 @default.
- W1527103851 cites W2081939122 @default.
- W1527103851 cites W2089522446 @default.
- W1527103851 cites W2090778914 @default.
- W1527103851 cites W2096614956 @default.
- W1527103851 cites W2098395709 @default.
- W1527103851 cites W2103997264 @default.
- W1527103851 cites W2104158696 @default.
- W1527103851 cites W2106697461 @default.
- W1527103851 cites W2109052299 @default.
- W1527103851 cites W2109922541 @default.
- W1527103851 cites W2113397827 @default.
- W1527103851 cites W2115686163 @default.
- W1527103851 cites W2117526699 @default.
- W1527103851 cites W2122538320 @default.
- W1527103851 cites W2124357826 @default.
- W1527103851 cites W2125068279 @default.
- W1527103851 cites W2126122106 @default.
- W1527103851 cites W2132584224 @default.
- W1527103851 cites W2137854993 @default.
- W1527103851 cites W2141614336 @default.
- W1527103851 cites W2141974913 @default.
- W1527103851 cites W2143074018 @default.
- W1527103851 cites W2143619637 @default.
- W1527103851 cites W2149190378 @default.
- W1527103851 cites W2172086325 @default.
- W1527103851 cites W2344734924 @default.
- W1527103851 cites W2346925206 @default.
- W1527103851 cites W2468566139 @default.
- W1527103851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2354921" @default.
- W1527103851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11291846" @default.
- W1527103851 hasPublicationYear "2001" @default.