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- W1527147512 abstract "This paper reports the results of two series of experiments. In one series it was estimated with the aid of 5-iodouracildeoxyriboside (IUdR) that in HEp-2 cells, Herpes simplex virus (HSV) DNA accumulates at an exponential rate between 4 and at least 14 hours after infection. The time required to duplicate one molecule of viral DNA cannot be more than 40 minutes; the time interval between completion of DNA and its encapsidation is estimated to be 120–150 minutes. In the second series, infected cells were exposed to IUdR or to puromycin for brief intervals of time. IUdR added to cells for brief intervals had no demonstrable effects during the first 2 hours. In cells exposed to IUdR during the third and fourth hours virus multiplication was delayed, but the rate of accumulation of virus was unaffected. However, the inhibition of virus multiplication in cells treated for 2 hours between 4 and 14 hours after infection could not be reversed. Incorporation of IUdR-H3 into viral DNA could not be shown. Brief treatment of infected cells with puromycin during the first 4 hours of infection delayed, but did not affect the rate of, viral DNA synthesis and virus maturation. The inhibition produced later in the infection could be reversed by withdrawing the drug. These results are interpreted as follows: (1) Protein synthesis must precede viral DNA synthesis. (2) The enzymes required for the utilization of thymidine in the synthesis of viral DNA are made approximately between the second and fourth hours after infection. The synthesis of these enzymes ceases after the onset of viral DNA synthesis. (3) The duplication of viral DNA begins when one or more specific precursors of DNA synthesis reach a critical concentration." @default.
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- W1527147512 date "1963-11-01" @default.
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- W1527147512 title "The multiplication of herpes simplex virus" @default.
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- W1527147512 doi "https://doi.org/10.1016/0042-6822(63)90209-5" @default.
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