FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1527445712> ?p ?o ?g. }

• W1527445712 endingPage "1643" @default.
• W1527445712 startingPage "1636" @default.
• W1527445712 abstract "Abstract Historically, conditioning for engraftment of hematopoietic stem cells has been nonspecific. In the present study, we characterized which cells in the recipient hematopoietic microenvironment prevent allogeneic marrow engraftment. Mice defective in production of αβ-TCR+, γδ-TCR+, αβ- plus γδ-TCR+, CD8+, or CD4+ cells were transplanted with MHC-disparate allogeneic bone marrow. Conditioning with 500 cGy total body irradiation (TBI) plus a single dose of cyclophosphamide (CyP) on day +2 establishes chimerism in normal recipients. When mice were conditioned with 300 cGy TBI plus a single dose of CyP on day +2, all engrafted, except wild-type controls and those defective in production of CD4+ T cells. Mice lacking both αβ- and γδ-TCR+ cells engrafted without conditioning, suggesting that both αβ- and γδ-TCR T cells in the host play critical and nonredundant roles in preventing engraftment of allogeneic bone marrow. CD8 knockout (KO) mice engrafted without TBI, but only if they received CyP on day +2 relative to the marrow infusion, showing that a CD8− cell was targeted by the CyP conditioning. The CD8+ cell effector function is mechanistically different from that for conventional T cells, and independent of CD4+ T helper cells because CD4 KO mice require substantially higher levels of conditioning than the other KO phenotypes. These results suggest that a number of cell populations with different mechanisms of action mediate resistance to engraftment of allogeneic marrow. Targeting of specific recipient cellular populations may permit conditioning approaches to allow mixed chimerism with minimal morbidity and could potentially avoid the requirement for myelotoxic agents altogether." @default.
• W1527445712 created "2016-06-24" @default.
• W1527445712 creator A5009753759 @default.
• W1527445712 creator A5051022402 @default.
• W1527445712 creator A5060383525 @default.
• W1527445712 creator A5073101823 @default.
• W1527445712 creator A5082588138 @default.
• W1527445712 creator A5083282651 @default.
• W1527445712 date "2002-02-15" @default.
• W1527445712 modified "2023-10-03" @default.
• W1527445712 title "CD8+, αβ-TCR+, and γδ-TCR+ Cells in the Recipient Hematopoietic Environment Mediate Resistance to Engraftment of Allogeneic Donor Bone Marrow" @default.
• W1527445712 cites W104932277 @default.
• W1527445712 cites W1511054799 @default.
• W1527445712 cites W1555915074 @default.
• W1527445712 cites W1569581528 @default.
• W1527445712 cites W1571056008 @default.
• W1527445712 cites W1596267923 @default.
• W1527445712 cites W1602146323 @default.
• W1527445712 cites W1662706554 @default.
• W1527445712 cites W1663536823 @default.
• W1527445712 cites W170775584 @default.
• W1527445712 cites W1900958902 @default.
• W1527445712 cites W1929184634 @default.
• W1527445712 cites W195094147 @default.
• W1527445712 cites W1964461041 @default.
• W1527445712 cites W1970082376 @default.
• W1527445712 cites W1977867111 @default.
• W1527445712 cites W1990053302 @default.
• W1527445712 cites W1990568245 @default.
• W1527445712 cites W1995711636 @default.
• W1527445712 cites W2014993931 @default.
• W1527445712 cites W2015322864 @default.
• W1527445712 cites W2019341074 @default.
• W1527445712 cites W2021847211 @default.
• W1527445712 cites W2024604633 @default.
• W1527445712 cites W2026842647 @default.
• W1527445712 cites W2027388097 @default.
• W1527445712 cites W2028537846 @default.
• W1527445712 cites W2032724666 @default.
• W1527445712 cites W2036897552 @default.
• W1527445712 cites W2046464172 @default.
• W1527445712 cites W2050763225 @default.
• W1527445712 cites W2058809104 @default.
• W1527445712 cites W2060819744 @default.
• W1527445712 cites W2064457820 @default.
• W1527445712 cites W2068136534 @default.
• W1527445712 cites W2068653310 @default.
• W1527445712 cites W2069669865 @default.
• W1527445712 cites W2072179705 @default.
• W1527445712 cites W2083079495 @default.
• W1527445712 cites W2091701225 @default.
• W1527445712 cites W2110272001 @default.
• W1527445712 cites W2150841203 @default.
• W1527445712 cites W2156895470 @default.
• W1527445712 cites W2209664554 @default.
• W1527445712 cites W2404611980 @default.
• W1527445712 cites W4236461081 @default.
• W1527445712 cites W4246835761 @default.
• W1527445712 cites W4248809278 @default.
• W1527445712 cites W4313341387 @default.
• W1527445712 cites W62199461 @default.
• W1527445712 doi "https://doi.org/10.4049/jimmunol.168.4.1636" @default.
• W1527445712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11823491" @default.
• W1527445712 hasPublicationYear "2002" @default.
• W1527445712 type Work @default.
• W1527445712 sameAs 1527445712 @default.
• W1527445712 citedByCount "27" @default.
• W1527445712 countsByYear W15274457122012 @default.
• W1527445712 countsByYear W15274457122013 @default.
• W1527445712 countsByYear W15274457122016 @default.
• W1527445712 countsByYear W15274457122017 @default.
• W1527445712 countsByYear W15274457122018 @default.
• W1527445712 countsByYear W15274457122020 @default.
• W1527445712 countsByYear W15274457122022 @default.
• W1527445712 crossrefType "journal-article" @default.
• W1527445712 hasAuthorship W1527445712A5009753759 @default.
• W1527445712 hasAuthorship W1527445712A5051022402 @default.
• W1527445712 hasAuthorship W1527445712A5060383525 @default.
• W1527445712 hasAuthorship W1527445712A5073101823 @default.
• W1527445712 hasAuthorship W1527445712A5082588138 @default.
• W1527445712 hasAuthorship W1527445712A5083282651 @default.
• W1527445712 hasBestOaLocation W15274457121 @default.
• W1527445712 hasConcept C109159458 @default.
• W1527445712 hasConcept C154317977 @default.
• W1527445712 hasConcept C167672396 @default.
• W1527445712 hasConcept C19317047 @default.
• W1527445712 hasConcept C202751555 @default.
• W1527445712 hasConcept C203014093 @default.
• W1527445712 hasConcept C2776090121 @default.
• W1527445712 hasConcept C2776694085 @default.
• W1527445712 hasConcept C2776755627 @default.
• W1527445712 hasConcept C2778880498 @default.
• W1527445712 hasConcept C2780007613 @default.
• W1527445712 hasConcept C28328180 @default.
• W1527445712 hasConcept C54355233 @default.
• W1527445712 hasConcept C86803240 @default.
• W1527445712 hasConcept C8891405 @default.
• W1527445712 hasConcept C95444343 @default.

• next