Matches in SemOpenAlex for { <https://semopenalex.org/work/W1527449024> ?p ?o ?g. }
- W1527449024 endingPage "1590" @default.
- W1527449024 startingPage "1578" @default.
- W1527449024 abstract "Adipose tissue contains thermogenic adipocytes (i.e., brown and brite/beige) that oxidize nutrients at exceptionally high rates via nonshivering thermogenesis. Its recent discovery in adult humans has opened up new avenues to fight obesity and related disorders such as diabetes. Here, we identified miR-26a and -26b as key regulators of human white and brite adipocyte differentiation. Both microRNAs are upregulated in early adipogenesis, and their inhibition prevented lipid accumulation while their overexpression accelerated it. Intriguingly, miR-26a significantly induced pathways related to energy dissipation, shifted mitochondrial morphology toward that seen in brown adipocytes, and promoted uncoupled respiration by markedly increasing the hallmark protein of brown fat, uncoupling protein 1. By combining in silico target prediction, transcriptomics, and an RNA interference screen, we identified the sheddase ADAM metallopeptidase domain 17 (ADAM17) as a direct target of miR-26 that mediated the observed effects on white and brite adipogenesis. These results point to a novel, critical role for the miR-26 family and its downstream effector ADAM17 in human adipocyte differentiation by promoting characteristics of energy-dissipating thermogenic adipocytes." @default.
- W1527449024 created "2016-06-24" @default.
- W1527449024 creator A5000192984 @default.
- W1527449024 creator A5002808509 @default.
- W1527449024 creator A5009860591 @default.
- W1527449024 creator A5015608393 @default.
- W1527449024 creator A5015792184 @default.
- W1527449024 creator A5022766966 @default.
- W1527449024 creator A5059558950 @default.
- W1527449024 creator A5063319666 @default.
- W1527449024 creator A5068178323 @default.
- W1527449024 creator A5070257889 @default.
- W1527449024 creator A5070615900 @default.
- W1527449024 creator A5073008608 @default.
- W1527449024 creator A5073028842 @default.
- W1527449024 creator A5084512710 @default.
- W1527449024 creator A5084820029 @default.
- W1527449024 creator A5087546848 @default.
- W1527449024 date "2014-05-23" @default.
- W1527449024 modified "2023-10-15" @default.
- W1527449024 title "MicroRNA-26 Family Is Required for Human Adipogenesis and Drives Characteristics of Brown Adipocytes" @default.
- W1527449024 cites W1958284284 @default.
- W1527449024 cites W1965079305 @default.
- W1527449024 cites W1968703258 @default.
- W1527449024 cites W1968963111 @default.
- W1527449024 cites W1970685293 @default.
- W1527449024 cites W1970829776 @default.
- W1527449024 cites W1973042766 @default.
- W1527449024 cites W1974058241 @default.
- W1527449024 cites W1975437957 @default.
- W1527449024 cites W1975568173 @default.
- W1527449024 cites W1976878696 @default.
- W1527449024 cites W1978337436 @default.
- W1527449024 cites W1979026577 @default.
- W1527449024 cites W1981478386 @default.
- W1527449024 cites W1981525131 @default.
- W1527449024 cites W1986098635 @default.
- W1527449024 cites W1989020172 @default.
- W1527449024 cites W1992941735 @default.
- W1527449024 cites W1993174948 @default.
- W1527449024 cites W1993500521 @default.
- W1527449024 cites W1993677020 @default.
- W1527449024 cites W1995253518 @default.
- W1527449024 cites W1995852794 @default.
- W1527449024 cites W1996333941 @default.
- W1527449024 cites W1997196734 @default.
- W1527449024 cites W1999649641 @default.
- W1527449024 cites W2000559235 @default.
- W1527449024 cites W2001290163 @default.
- W1527449024 cites W2005827500 @default.
- W1527449024 cites W2006518765 @default.
- W1527449024 cites W2008632158 @default.
- W1527449024 cites W2025726874 @default.
- W1527449024 cites W2026099724 @default.
- W1527449024 cites W2027753197 @default.
- W1527449024 cites W2034804253 @default.
- W1527449024 cites W2036842448 @default.
- W1527449024 cites W2038578669 @default.
- W1527449024 cites W2040328785 @default.
- W1527449024 cites W2041069797 @default.
- W1527449024 cites W2047687395 @default.
- W1527449024 cites W2059992589 @default.
- W1527449024 cites W2065566217 @default.
- W1527449024 cites W2074881372 @default.
- W1527449024 cites W2075494055 @default.
- W1527449024 cites W2076287538 @default.
- W1527449024 cites W2080210415 @default.
- W1527449024 cites W2083602312 @default.
- W1527449024 cites W2088149570 @default.
- W1527449024 cites W2091158130 @default.
- W1527449024 cites W2091614510 @default.
- W1527449024 cites W2098457930 @default.
- W1527449024 cites W2101117089 @default.
- W1527449024 cites W2103239302 @default.
- W1527449024 cites W2104827888 @default.
- W1527449024 cites W2107500412 @default.
- W1527449024 cites W2109822586 @default.
- W1527449024 cites W2114821999 @default.
- W1527449024 cites W2127686290 @default.
- W1527449024 cites W2128731054 @default.
- W1527449024 cites W2132358997 @default.
- W1527449024 cites W2133009318 @default.
- W1527449024 cites W2134018311 @default.
- W1527449024 cites W2136426539 @default.
- W1527449024 cites W2140477106 @default.
- W1527449024 cites W2143516374 @default.
- W1527449024 cites W2151064573 @default.
- W1527449024 cites W2151922790 @default.
- W1527449024 cites W2153942347 @default.
- W1527449024 cites W2154238043 @default.
- W1527449024 cites W2157916750 @default.
- W1527449024 cites W2165742641 @default.
- W1527449024 cites W2167557255 @default.
- W1527449024 cites W2170874580 @default.
- W1527449024 cites W38795132 @default.
- W1527449024 doi "https://doi.org/10.1002/stem.1603" @default.
- W1527449024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24375761" @default.
- W1527449024 hasPublicationYear "2014" @default.