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- W1527492258 abstract "In biomedical research, understanding and defining the origin of diseases and their effect on multiple organs is a necessity. It has to be done at several levels: genomic, transcriptomic, proteomic and metabolomic. When the origin of a disease is suspected to be monogenic, the best approach to unravel its cause is obviously genomic. When the behaviour or the aggression of a cancer and its response to therapy are related to multiple gene modifications or expression deregulation, tissue biopsies should be analysed at transcriptomic levels by reverse transcription PCR and DNA microarrays. When the disease impacts mostly on the internal environment and is due to the accumulation of ‘toxic’ material affecting multiple organs, proteomic and metabolomic approaches are required. The present chapter discuss how proteomics can be used in medicine for basic or applied research, in fundamental or clinical domains, to unravel disease processes or to discover biomarkers and therapeutic targets." @default.
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- W1527492258 date "2007-01-01" @default.
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- W1527492258 title "Biomedical Applications of Proteomics" @default.
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- W1527492258 doi "https://doi.org/10.1007/978-3-540-72910-5_9" @default.
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