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- W1527772460 abstract "Abstract 6β-Hydroxylation of chenodeoxycholic acid-24-14C and taurochenodeoxycholic acid-24-14C was demonstrated in vitro by cell-free preparations of rat liver. The enzymic activity, requiring O2 and NADPH, was located in the microsomes prepared in 0.1 m phosphate buffer and could be stimulated by addition of the 105,000 x g supernatant fluid. The microsomal fraction prepared in 0.01 m phosphate buffer had full activity and was not further stimulated by the 105,000 x g supernatant fluid. A clear extract made by suspending this microsomal pellet in 1.0 m phosphate and subsequently centrifuging it at 105,000 x g contained the complete 6β-hydroxylase system. The activity of the 1.0 m phosphate extract was inhibited by sulfhydryl reagents, Cu++, cytochrome c, and CO. The inhibition by CO could be reversed by light. The presence of cytochrome b5 and the CO-binding pigment, P-450, in the extract was detected by differential spectrophotometry." @default.
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- W1527772460 date "1968-06-01" @default.
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- W1527772460 title "Enzymic Studies of Bile Acid Metabolism" @default.
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- W1527772460 doi "https://doi.org/10.1016/s0021-9258(18)93334-x" @default.
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