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- W1527773978 abstract "Summary The effect of daily treatment with amethopterin (MTX) and 3′,5′-dichloroamethopterin (DCM) on formate-C 14 incorporation in vivo into acid-soluble adenine of spleen and liver was studied in normal mice and in mice bearing advanced leukemia L1210. On the basis of previous findings of optimal therapeutic levels in leukemic mice, daily doses of 0.7 mg/kg of MTX or 75 mg/kg of DCM were selected for these studies. Both MTX and DCM led to sustained inhibition of formate incorporation in normal spleen, with a cumulative effect appearing after several treatments. Discontinuation of treatment was followed after several days by an increase in formate incorporation above the untreated control level and by temporary spleen enlargement. In leukemic mice, DCM caused a cumulative and sustained inhibition and arrested leukemic infiltration of spleen and liver, whereas MTX produced an intermittent pattern of inhibition in spleen and failed to prevent its infiltration. Cessation of therapy with DCM was followed by renewed leukemic infiltration of spleen and liver, with formate incorporation levels characteristic of leukemic tissues. The findings are discussed with respect to the biochemical actions of the drugs, their toxicity to the host, and their antileukemic effectiveness." @default.
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- W1527773978 date "1962-01-01" @default.
- W1527773978 modified "2023-09-23" @default.
- W1527773978 title "Incorporation of formate-C-14 in normal and leukemic mice during extended treatment with amethopterin and 3',5'-dichloramethopterin." @default.
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