FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528086324> ?p ?o ?g. }

• W1528086324 endingPage "2920" @default.
• W1528086324 startingPage "2909" @default.
• W1528086324 abstract "The endocannabinoid system is a conserved system involved in the modulation of several physiologic processes, from the activity of the central nervous system to reproduction. Type 1 cannabinoid receptor (CNR1) cDNA was cloned from the brain and testis of the anuran amphibian, the frog Rana esculenta. Nucleotide identity ranging from 62.6% to 81.9% is observed among vertebrates. The reading frame encoded a protein of 462 amino acids (FCNR1) with all the properties of a membrane G-coupled receptor. Alignments of FCNR1 with those of other vertebrates revealed amino acid identity ranging from 61.9% to 88.1%; critical domains for CNR1 functionality were conserved in the frog. As nucleotide differences of cnr1 cDNA were observed in brain and testis, the genomic sequence of the cnr1 gene was also determined in the same tissue preparations. Nucleotide changes in codons 5, 30, 70, 186, 252 and 408 were observed when cDNA and genomic DNA were compared; the nucleotide differences did not affect the predicted amino acid sequences, except for changes in codons 70 and 408. Interestingly, the predicted RNA folding was strongly affected by different nucleotide sequences. Comparison of cnr1 mRNA sequences available in GenBank with the corresponding genomic sequences revealed that also in human, rat, zebrafish and pufferfish, nucleotide changes between mRNA and genomic sequences occurred. Furthermore, amino acid sequences deduced from both mRNA and the genome were compared among vertebrates, and also in pufferfish the nucleotide changes corresponded to modifications in the amino acid sequence. The present results indicate for the first time that changes in nucleotides may occur in cnr1 mRNA maturation and that this phenomenon might not be restricted to the frog." @default.
• W1528086324 created "2016-06-24" @default.
• W1528086324 creator A5006818846 @default.
• W1528086324 creator A5029210666 @default.
• W1528086324 creator A5032067791 @default.
• W1528086324 creator A5052447169 @default.
• W1528086324 creator A5085159052 @default.
• W1528086324 date "2007-05-21" @default.
• W1528086324 modified "2023-09-28" @default.
• W1528086324 title "Cloning of type 1 cannabinoid receptor in Rana esculenta reveals differences between genomic sequence and cDNA" @default.
• W1528086324 cites W1539656550 @default.
• W1528086324 cites W1627321564 @default.
• W1528086324 cites W172430044 @default.
• W1528086324 cites W1811580786 @default.
• W1528086324 cites W1966451239 @default.
• W1528086324 cites W1971909322 @default.
• W1528086324 cites W1971967634 @default.
• W1528086324 cites W1974642601 @default.
• W1528086324 cites W1975921008 @default.
• W1528086324 cites W1982459425 @default.
• W1528086324 cites W1987717082 @default.
• W1528086324 cites W1990893297 @default.
• W1528086324 cites W1991461690 @default.
• W1528086324 cites W2001360233 @default.
• W1528086324 cites W2004382859 @default.
• W1528086324 cites W2007952664 @default.
• W1528086324 cites W2009818318 @default.
• W1528086324 cites W2014045586 @default.
• W1528086324 cites W2020827621 @default.
• W1528086324 cites W2028105754 @default.
• W1528086324 cites W2028831542 @default.
• W1528086324 cites W2036565829 @default.
• W1528086324 cites W2049930242 @default.
• W1528086324 cites W2055307787 @default.
• W1528086324 cites W2056470398 @default.
• W1528086324 cites W2062867847 @default.
• W1528086324 cites W2063716145 @default.
• W1528086324 cites W2064876535 @default.
• W1528086324 cites W2065163203 @default.
• W1528086324 cites W2077084434 @default.
• W1528086324 cites W2080698433 @default.
• W1528086324 cites W2102098190 @default.
• W1528086324 cites W2110768532 @default.
• W1528086324 cites W2125104309 @default.
• W1528086324 cites W2137184526 @default.
• W1528086324 cites W2141157874 @default.
• W1528086324 cites W2143671912 @default.
• W1528086324 cites W2167845627 @default.
• W1528086324 cites W4211202477 @default.
• W1528086324 cites W4250767150 @default.
• W1528086324 doi "https://doi.org/10.1111/j.1742-4658.2007.05824.x" @default.
• W1528086324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17518972" @default.
• W1528086324 hasPublicationYear "2007" @default.
• W1528086324 type Work @default.
• W1528086324 sameAs 1528086324 @default.
• W1528086324 citedByCount "18" @default.
• W1528086324 countsByYear W15280863242012 @default.
• W1528086324 countsByYear W15280863242013 @default.
• W1528086324 countsByYear W15280863242014 @default.
• W1528086324 countsByYear W15280863242016 @default.
• W1528086324 countsByYear W15280863242017 @default.
• W1528086324 crossrefType "journal-article" @default.
• W1528086324 hasAuthorship W1528086324A5006818846 @default.
• W1528086324 hasAuthorship W1528086324A5029210666 @default.
• W1528086324 hasAuthorship W1528086324A5032067791 @default.
• W1528086324 hasAuthorship W1528086324A5052447169 @default.
• W1528086324 hasAuthorship W1528086324A5085159052 @default.
• W1528086324 hasConcept C104317684 @default.
• W1528086324 hasConcept C153911025 @default.
• W1528086324 hasConcept C167625842 @default.
• W1528086324 hasConcept C17757408 @default.
• W1528086324 hasConcept C187882448 @default.
• W1528086324 hasConcept C47289529 @default.
• W1528086324 hasConcept C515207424 @default.
• W1528086324 hasConcept C54355233 @default.
• W1528086324 hasConcept C79029880 @default.
• W1528086324 hasConcept C84148353 @default.
• W1528086324 hasConcept C86803240 @default.
• W1528086324 hasConceptScore W1528086324C104317684 @default.
• W1528086324 hasConceptScore W1528086324C153911025 @default.
• W1528086324 hasConceptScore W1528086324C167625842 @default.
• W1528086324 hasConceptScore W1528086324C17757408 @default.
• W1528086324 hasConceptScore W1528086324C187882448 @default.
• W1528086324 hasConceptScore W1528086324C47289529 @default.
• W1528086324 hasConceptScore W1528086324C515207424 @default.
• W1528086324 hasConceptScore W1528086324C54355233 @default.
• W1528086324 hasConceptScore W1528086324C79029880 @default.
• W1528086324 hasConceptScore W1528086324C84148353 @default.
• W1528086324 hasConceptScore W1528086324C86803240 @default.
• W1528086324 hasIssue "11" @default.
• W1528086324 hasLocation W15280863241 @default.
• W1528086324 hasLocation W15280863242 @default.
• W1528086324 hasOpenAccess W1528086324 @default.
• W1528086324 hasPrimaryLocation W15280863241 @default.
• W1528086324 hasRelatedWork W1979663996 @default.
• W1528086324 hasRelatedWork W1987905608 @default.
• W1528086324 hasRelatedWork W2029933062 @default.
• W1528086324 hasRelatedWork W2042379947 @default.

• next