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• W1528130089 abstract "Sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose (25 mg/kg) streptozotocin. After intragastrical perfusion of sericin for 35 days, blood glucose levels significantly declined, and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased. However, the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats. These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells, and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells." @default.
• W1528130089 created "2016-06-24" @default.
• W1528130089 creator A5024644382 @default.
• W1528130089 creator A5060533134 @default.
• W1528130089 creator A5069813415 @default.
• W1528130089 creator A5088945316 @default.
• W1528130089 date "2013-02-25" @default.
• W1528130089 modified "2023-09-27" @default.
• W1528130089 title "Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells." @default.
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• W1528130089 doi "https://doi.org/10.3969/j.issn.1673-5374.2013.06.003" @default.
• W1528130089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146054" @default.
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• W1528130089 hasPublicationYear "2013" @default.
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