FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528169997> ?p ?o ?g. }

• W1528169997 endingPage "2676" @default.
• W1528169997 startingPage "2668" @default.
• W1528169997 abstract "Neuropilin 1 (NRP1), a receptor of vascular endothelial growth factor (VEGF), promotes angiogenesis, tumor growth, tumor invasion and metastasis. However, the function of NRP1 in melanoma progression, as well as the effect of NRP1 expression on the prognosis of patients with melanoma remains unknown. In the present study, NRP1 expression was examined in 460 cases of melanocytic lesions (28 common nevi, 51 dysplastic nevi, 250 primary melanoma and 131 metastatic melanoma) at different stages, using a tissue microarray. The correlation of NRP1 expression with melanoma progression, and its prognostic value in patients with melanoma was examined. In addition, the correlation between matrix metalloproteinase 2 (MMP2) and NRP1 expression in patients with melanoma was analyzed. The results demonstrated that NRP1 expression was significantly increased in primary (56%) and metastatic melanoma (62%), compared with common nevi (11%) and dysplastic nevi (24%). Notably, increased NRP1 expression was correlated with a poorer overall, and disease-specific, 10-year survival (P=0.03 and P=0.002, respectively). Multivariate Cox regression analyses indicated that NRP1 is an independent prognostic marker for melanoma. Furthermore, a significant positive correlation between NRP1 and MMP2 expression in melanoma biopsies was observed, and their concomitant expression was closely correlated with melanoma patient survival, further supporting the hypothesis that the expression of NRP1 is associated with melanoma invasion and metastasis. In conclusion, increased NRP1 expression is associated with disease progression and reduced survival in patients with melanoma, and is a promising prognostic molecular marker for this disease." @default.
• W1528169997 created "2016-06-24" @default.
• W1528169997 creator A5000756423 @default.
• W1528169997 creator A5038431136 @default.
• W1528169997 creator A5046228592 @default.
• W1528169997 creator A5064830505 @default.
• W1528169997 creator A5074942308 @default.
• W1528169997 creator A5080952282 @default.
• W1528169997 creator A5087892686 @default.
• W1528169997 date "2015-05-07" @default.
• W1528169997 modified "2023-10-10" @default.
• W1528169997 title "Increased expression of neuropilin 1 in melanoma progression and its prognostic significance in patients with melanoma" @default.
• W1528169997 cites W1921756464 @default.
• W1528169997 cites W1968122399 @default.
• W1528169997 cites W1977979223 @default.
• W1528169997 cites W1983521199 @default.
• W1528169997 cites W1988186967 @default.
• W1528169997 cites W1990521757 @default.
• W1528169997 cites W1992885568 @default.
• W1528169997 cites W1996801596 @default.
• W1528169997 cites W2011770381 @default.
• W1528169997 cites W2033744588 @default.
• W1528169997 cites W2034992352 @default.
• W1528169997 cites W2042349690 @default.
• W1528169997 cites W2046285899 @default.
• W1528169997 cites W2055637504 @default.
• W1528169997 cites W2056808575 @default.
• W1528169997 cites W2059781922 @default.
• W1528169997 cites W2067755505 @default.
• W1528169997 cites W2067817921 @default.
• W1528169997 cites W2069195505 @default.
• W1528169997 cites W2084480843 @default.
• W1528169997 cites W2088422531 @default.
• W1528169997 cites W2103176225 @default.
• W1528169997 cites W2110612000 @default.
• W1528169997 cites W2118863192 @default.
• W1528169997 cites W2125156680 @default.
• W1528169997 cites W2129318139 @default.
• W1528169997 cites W2133906762 @default.
• W1528169997 cites W2135493854 @default.
• W1528169997 cites W2135743455 @default.
• W1528169997 cites W2136023770 @default.
• W1528169997 cites W2161817637 @default.
• W1528169997 cites W2171275402 @default.
• W1528169997 cites W2312553706 @default.
• W1528169997 cites W4244068819 @default.
• W1528169997 doi "https://doi.org/10.3892/mmr.2015.3752" @default.
• W1528169997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4464456" @default.
• W1528169997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25954957" @default.
• W1528169997 hasPublicationYear "2015" @default.
• W1528169997 type Work @default.
• W1528169997 sameAs 1528169997 @default.
• W1528169997 citedByCount "25" @default.
• W1528169997 countsByYear W15281699972015 @default.
• W1528169997 countsByYear W15281699972016 @default.
• W1528169997 countsByYear W15281699972017 @default.
• W1528169997 countsByYear W15281699972018 @default.
• W1528169997 countsByYear W15281699972019 @default.
• W1528169997 countsByYear W15281699972020 @default.
• W1528169997 countsByYear W15281699972021 @default.
• W1528169997 countsByYear W15281699972022 @default.
• W1528169997 countsByYear W15281699972023 @default.
• W1528169997 crossrefType "journal-article" @default.
• W1528169997 hasAuthorship W1528169997A5000756423 @default.
• W1528169997 hasAuthorship W1528169997A5038431136 @default.
• W1528169997 hasAuthorship W1528169997A5046228592 @default.
• W1528169997 hasAuthorship W1528169997A5064830505 @default.
• W1528169997 hasAuthorship W1528169997A5074942308 @default.
• W1528169997 hasAuthorship W1528169997A5080952282 @default.
• W1528169997 hasAuthorship W1528169997A5087892686 @default.
• W1528169997 hasBestOaLocation W15281699971 @default.
• W1528169997 hasConcept C121608353 @default.
• W1528169997 hasConcept C126322002 @default.
• W1528169997 hasConcept C142724271 @default.
• W1528169997 hasConcept C143998085 @default.
• W1528169997 hasConcept C167734588 @default.
• W1528169997 hasConcept C193270364 @default.
• W1528169997 hasConcept C204232928 @default.
• W1528169997 hasConcept C2777025900 @default.
• W1528169997 hasConcept C2777658100 @default.
• W1528169997 hasConcept C2779013556 @default.
• W1528169997 hasConcept C2780394083 @default.
• W1528169997 hasConcept C2780699576 @default.
• W1528169997 hasConcept C34425596 @default.
• W1528169997 hasConcept C502942594 @default.
• W1528169997 hasConcept C71924100 @default.
• W1528169997 hasConceptScore W1528169997C121608353 @default.
• W1528169997 hasConceptScore W1528169997C126322002 @default.
• W1528169997 hasConceptScore W1528169997C142724271 @default.
• W1528169997 hasConceptScore W1528169997C143998085 @default.
• W1528169997 hasConceptScore W1528169997C167734588 @default.
• W1528169997 hasConceptScore W1528169997C193270364 @default.
• W1528169997 hasConceptScore W1528169997C204232928 @default.
• W1528169997 hasConceptScore W1528169997C2777025900 @default.
• W1528169997 hasConceptScore W1528169997C2777658100 @default.
• W1528169997 hasConceptScore W1528169997C2779013556 @default.
• W1528169997 hasConceptScore W1528169997C2780394083 @default.
• W1528169997 hasConceptScore W1528169997C2780699576 @default.

• next