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• W1528183926 abstract "NB-598, (E)N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bith iophen-5-yl)methoxy]benzene-methanamine, was found to inhibit human microsomal squalene epoxidase (from Hep G2 cells) in a competitive manner. NB-598 inhibited cholesterol synthesis from [14C]acetate dose dependently in Hep G2 cells and increased the intracellular radioactivity of squalene. A single oral administration of NB-598 inhibited cholesterol synthesis from [14C]acetate in rats. Moreover, multiple oral administration of NB-598 to dogs decreased serum total and low density lipoprotein cholesterol levels and increased serum squalene levels. After termination of treatment, the reduced serum cholesterol and increased squalene levels returned to their control values." @default.
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• W1528183926 date "1990-10-01" @default.
• W1528183926 modified "2023-10-16" @default.
• W1528183926 title "NB-598: a potent competitive inhibitor of squalene epoxidase." @default.
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• W1528183926 doi "https://doi.org/10.1016/s0021-9258(17)44716-8" @default.
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