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- W1528219829 abstract "Breast carcinoma cells and embryonic progenitors similarly implement stem cell-associated signaling pathways to sustain continued growth and plasticity. Indeed, recent studies have implicated signaling pathways, including those associated with the Notch, and Transforming Growth Factor-Beta (TGF-beta) superfamilies, as instrumental to both embryological development and breast cancer progression. In particular, Nodal, an embryonic morphogen belonging to the TGF-beta superfamily, and its co-receptor, Cripto-1, are requisite to both embryogenesis and mammary gland maturation. Moreover, these developmental proteins have been shown to promote breast cancer progression. Here, we review the role of Nodal and its co-receptor Cripto-1 during development and we describe how this signaling pathway may be involved in breast cancer tumorigenesis. Moreover, we emphasize the potential utility of this signaling pathway as a novel target for the treatment and diagnosis of breast cancer." @default.
- W1528219829 created "2016-06-24" @default.
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- W1528219829 creator A5061394739 @default.
- W1528219829 creator A5069867977 @default.
- W1528219829 creator A5075432941 @default.
- W1528219829 date "2008-10-31" @default.
- W1528219829 modified "2023-09-23" @default.
- W1528219829 title "Emerging Roles of Nodal and Cripto-1: From Embryogenesis to Breast Cancer Progression" @default.
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