Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528249546> ?p ?o ?g. }
- W1528249546 endingPage "435" @default.
- W1528249546 startingPage "207" @default.
- W1528249546 abstract "This chapter provides a synoptic review of several investigations that have converged and synergistically interacted to develop clinically useful anti-inflammatory therapeutics from inhibitors of selectin–ligand interactions. The chapter presents a summary of early cell-physiological studies with monoclonal antibodies that led to the independent discoveries of endothelial (E), platelet (P), and leukocyte (L)-selectins in the fields of vascular physiology, platelet activation, and lymphocyte trafficking. The chapter also discusses the results of these investigations, important insights are provided on the cellular distribution and mode of expression of the selectins, and their roles in acute and chronic inflammation. Application of the methods of molecular genetics has led to the molecular characterization and expression cloning of the selectins. The typical domain structure of the selectins, most notably the N-terminal lectin domain with its high degree of homology, not only among the selectins but also with previously known, C-(Ca2+)-type mammalian lectins, such as liver lectin or mannose-binding proteins is presented. The chapter also discusses the structures of the carbohydrate determinants that would physiologically bind to the lectin domains of the selectins, leading to the identification of the common sialyl-Lewisx (sLex) tetrasaccharide motif." @default.
- W1528249546 created "2016-06-24" @default.
- W1528249546 creator A5033421296 @default.
- W1528249546 date "2001-01-01" @default.
- W1528249546 modified "2023-09-23" @default.
- W1528249546 title "The chemistry of oligosaccharide ligands of selectins: Significance for the development of new immunomodulatory medicines" @default.
- W1528249546 cites W102896681 @default.
- W1528249546 cites W1131515033 @default.
- W1528249546 cites W1146978950 @default.
- W1528249546 cites W131247432 @default.
- W1528249546 cites W1410466600 @default.
- W1528249546 cites W1483023874 @default.
- W1528249546 cites W1488034370 @default.
- W1528249546 cites W149062220 @default.
- W1528249546 cites W1492512703 @default.
- W1528249546 cites W1494017401 @default.
- W1528249546 cites W1494073707 @default.
- W1528249546 cites W1505966612 @default.
- W1528249546 cites W1508075941 @default.
- W1528249546 cites W1509009405 @default.
- W1528249546 cites W1513555169 @default.
- W1528249546 cites W1515695497 @default.
- W1528249546 cites W1516652978 @default.
- W1528249546 cites W1523977310 @default.
- W1528249546 cites W1527670929 @default.
- W1528249546 cites W1531203186 @default.
- W1528249546 cites W1535728477 @default.
- W1528249546 cites W1539737337 @default.
- W1528249546 cites W1542978449 @default.
- W1528249546 cites W1545524676 @default.
- W1528249546 cites W1545973549 @default.
- W1528249546 cites W1546312651 @default.
- W1528249546 cites W1549735501 @default.
- W1528249546 cites W1549953248 @default.
- W1528249546 cites W1551592047 @default.
- W1528249546 cites W1553410372 @default.
- W1528249546 cites W1557022910 @default.
- W1528249546 cites W1559138834 @default.
- W1528249546 cites W1566087596 @default.
- W1528249546 cites W1567197932 @default.
- W1528249546 cites W1567285907 @default.
- W1528249546 cites W1568834538 @default.
- W1528249546 cites W1569726016 @default.
- W1528249546 cites W1570768589 @default.
- W1528249546 cites W1572198013 @default.
- W1528249546 cites W1573617710 @default.
- W1528249546 cites W1574287985 @default.
- W1528249546 cites W1575885714 @default.
- W1528249546 cites W1579116665 @default.
- W1528249546 cites W1580023435 @default.
- W1528249546 cites W1580259448 @default.
- W1528249546 cites W1582197136 @default.
- W1528249546 cites W1584822782 @default.
- W1528249546 cites W1585720781 @default.
- W1528249546 cites W1593852866 @default.
- W1528249546 cites W1595476916 @default.
- W1528249546 cites W1598610569 @default.
- W1528249546 cites W1600148840 @default.
- W1528249546 cites W1601452086 @default.
- W1528249546 cites W1603930781 @default.
- W1528249546 cites W1628568780 @default.
- W1528249546 cites W1633199640 @default.
- W1528249546 cites W1633393203 @default.
- W1528249546 cites W1634312914 @default.
- W1528249546 cites W1635353275 @default.
- W1528249546 cites W1638424324 @default.
- W1528249546 cites W1644503518 @default.
- W1528249546 cites W1646941904 @default.
- W1528249546 cites W1661591147 @default.
- W1528249546 cites W1661742214 @default.
- W1528249546 cites W1668880997 @default.
- W1528249546 cites W1670186976 @default.
- W1528249546 cites W1751281485 @default.
- W1528249546 cites W1754937767 @default.
- W1528249546 cites W1777863255 @default.
- W1528249546 cites W1806496211 @default.
- W1528249546 cites W1824700770 @default.
- W1528249546 cites W1864383965 @default.
- W1528249546 cites W1869209338 @default.
- W1528249546 cites W1870555175 @default.
- W1528249546 cites W1893651774 @default.
- W1528249546 cites W1895563716 @default.
- W1528249546 cites W1898209536 @default.
- W1528249546 cites W1964316590 @default.
- W1528249546 cites W1964712271 @default.
- W1528249546 cites W1965103923 @default.
- W1528249546 cites W1965562807 @default.
- W1528249546 cites W1966015886 @default.
- W1528249546 cites W1966054630 @default.
- W1528249546 cites W1966126000 @default.
- W1528249546 cites W1966286149 @default.
- W1528249546 cites W1966419565 @default.
- W1528249546 cites W1966539382 @default.
- W1528249546 cites W1968072780 @default.
- W1528249546 cites W1969302413 @default.
- W1528249546 cites W1969328680 @default.
- W1528249546 cites W1970026253 @default.
- W1528249546 cites W1970533409 @default.