Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528278049> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1528278049 abstract "Gene-regulatory biomolecules such as splice-correcting oligonucleotides and anti-microRNA oligonucleotides are important tools in the struggle to understand and treat genetic disorders caused by defective gene expression or aberrant splicing. However, oligonucleotides generally suffer from low bioavailability, hence requiring efficient and non-toxic delivery vectors to reach their targets. Cell-penetrating peptides constitute a promising category of carrier molecules for intracellular delivery of bioactive cargo. In this study we present a novel cell-penetrating peptide, PepFect15, comprising the previously reported PepFect14 peptide modified with endosomolytic trifluoromethylquinoline moieties to facilitate endosomal escape. Pepfect15 efficiently delivers both splice-correcting oligonucleotides and anti-microRNA oligonucleotides into cells through a non-covalent complexation strategy. To our knowledge this is the first work that describes peptide-mediated anti-microRNA delivery. The peptide and its cargo form stable, negatively charged nanoparticles that are taken up by cells largely through scavenger receptor type A mediated endocytosis." @default.
- W1528278049 created "2016-06-24" @default.
- W1528278049 creator A5002574049 @default.
- W1528278049 date "2013-01-01" @default.
- W1528278049 modified "2023-09-23" @default.
- W1528278049 title "Cell-penetrating peptides : an uptake mechanism a a new endosomolytic peptide" @default.
- W1528278049 hasPublicationYear "2013" @default.
- W1528278049 type Work @default.
- W1528278049 sameAs 1528278049 @default.
- W1528278049 citedByCount "0" @default.
- W1528278049 crossrefType "journal-article" @default.
- W1528278049 hasAuthorship W1528278049A5002574049 @default.
- W1528278049 hasConcept C102747710 @default.
- W1528278049 hasConcept C104317684 @default.
- W1528278049 hasConcept C129312508 @default.
- W1528278049 hasConcept C135983454 @default.
- W1528278049 hasConcept C1491633281 @default.
- W1528278049 hasConcept C185592680 @default.
- W1528278049 hasConcept C2776929087 @default.
- W1528278049 hasConcept C2779281246 @default.
- W1528278049 hasConcept C28005876 @default.
- W1528278049 hasConcept C54009773 @default.
- W1528278049 hasConcept C55493867 @default.
- W1528278049 hasConcept C70721500 @default.
- W1528278049 hasConcept C79747257 @default.
- W1528278049 hasConcept C86803240 @default.
- W1528278049 hasConcept C95444343 @default.
- W1528278049 hasConceptScore W1528278049C102747710 @default.
- W1528278049 hasConceptScore W1528278049C104317684 @default.
- W1528278049 hasConceptScore W1528278049C129312508 @default.
- W1528278049 hasConceptScore W1528278049C135983454 @default.
- W1528278049 hasConceptScore W1528278049C1491633281 @default.
- W1528278049 hasConceptScore W1528278049C185592680 @default.
- W1528278049 hasConceptScore W1528278049C2776929087 @default.
- W1528278049 hasConceptScore W1528278049C2779281246 @default.
- W1528278049 hasConceptScore W1528278049C28005876 @default.
- W1528278049 hasConceptScore W1528278049C54009773 @default.
- W1528278049 hasConceptScore W1528278049C55493867 @default.
- W1528278049 hasConceptScore W1528278049C70721500 @default.
- W1528278049 hasConceptScore W1528278049C79747257 @default.
- W1528278049 hasConceptScore W1528278049C86803240 @default.
- W1528278049 hasConceptScore W1528278049C95444343 @default.
- W1528278049 hasLocation W15282780491 @default.
- W1528278049 hasOpenAccess W1528278049 @default.
- W1528278049 hasPrimaryLocation W15282780491 @default.
- W1528278049 hasRelatedWork W1501998524 @default.
- W1528278049 hasRelatedWork W1970690207 @default.
- W1528278049 hasRelatedWork W1972440560 @default.
- W1528278049 hasRelatedWork W1982519048 @default.
- W1528278049 hasRelatedWork W1999745075 @default.
- W1528278049 hasRelatedWork W2000295852 @default.
- W1528278049 hasRelatedWork W2003726865 @default.
- W1528278049 hasRelatedWork W2047534125 @default.
- W1528278049 hasRelatedWork W2051094596 @default.
- W1528278049 hasRelatedWork W2068629715 @default.
- W1528278049 hasRelatedWork W2082175825 @default.
- W1528278049 hasRelatedWork W2086752617 @default.
- W1528278049 hasRelatedWork W2093198351 @default.
- W1528278049 hasRelatedWork W2120466274 @default.
- W1528278049 hasRelatedWork W2151163354 @default.
- W1528278049 hasRelatedWork W242113310 @default.
- W1528278049 hasRelatedWork W258195840 @default.
- W1528278049 hasRelatedWork W2801513916 @default.
- W1528278049 hasRelatedWork W3096996300 @default.
- W1528278049 hasRelatedWork W3195998156 @default.
- W1528278049 isParatext "false" @default.
- W1528278049 isRetracted "false" @default.
- W1528278049 magId "1528278049" @default.
- W1528278049 workType "article" @default.