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- W1528297898 abstract "Abstract The intensive research and development of antisense oligonucleotides in the past decades has refined our knowledge of this class of molecules, and they are now recognized as potent reagents for gene‐target validation and therapeutic uses. Within this field, a very promising class is locked nucleic acid (LNA). In recent years, the number of applications for LNA in basic research, molecular diagnostics, and therapeutics has expanded continuously. In this article, the general biophysical, biochemical, and pharmacological properties of LNA will be summarised. The ability of LNA oligonucleotides to target both coding and noncoding RNAs effectively and specifically via different modes of action will be discussed. Several LNA oligonucleotides have completed preclinical toxicology and are now tested in clinical trials. The status of one drug candidate will be presented briefly at the end of the article." @default.
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- W1528297898 date "2008-05-15" @default.
- W1528297898 modified "2023-10-10" @default.
- W1528297898 title "Locked Nucleic Acids" @default.
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- W1528297898 doi "https://doi.org/10.1002/9780470048672.wecb516" @default.
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