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- W1528360918 abstract "vi Chapter 1: Introduction 1 Breast Cancer 1 Survival and Growth Factors 2 Molecular Chaperones 5 Stress and the Cancer Cell 7 Hsp70 Inhibitors 9 References 12 Chapter 2: Facilitating Akt Clearance Via Manipulation of Hsp70 ....... 16 Abstract 16 Introduction 17 Materials and Methods 19 Cell Lines 19 Antibodies, Plasmids, siRNAs, and Chemicals 20 Cell Culture and Transfection 20 Protein Collection, Quantitation, and Western Blotting .... 21 In-Cell Western 22 LDH Assay 22 Results 26 Hsp70 and Hsc70 reciprocally affect Akt levels 26 Hsc70 modulates Akt levels indirectly via Hsp70 24 Inhibition of Hsp70 ATPase function reduces Akt levels ... 25 Activators of Hsp70 ATPase function facilitate Akt accumulation 26 Despite pluripotency, phenothiazines primarily affect Akt via Hsp70 modulation 27 Phenothiazines selectively kill breast cancer cells 28 Discussion 30 Acknowledgements 37 References 38" @default.
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- W1528360918 date "2012-01-01" @default.
- W1528360918 modified "2023-09-27" @default.
- W1528360918 title "The Role of Hsp70 in Cancer: A Study of the Hsp70 / Akt Relationship" @default.
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