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• W1528483417 abstract "Cancer immunotherapy aspires to treat malignant disease by activating cancer specific immune responses. It is generally accepted that the latter can only be achieved by an approach in which tumor specific T cells are educated to recognize and kill tumor cells, whilst they are furthermore empowered to overcome immunosuppressive mechanisms present both at peripheral sites and in the tumor environment. Dendritic cells (DCs) have been extensively explored as a cellular vaccine for the stimulation of tumor specific T cells. Several strategies have been devised to manipulate these cells to become strongly activated tumor associated antigen (TAA) presenting cells. Our growing knowledge on the biology of DCs and the costimulatory as well as inhibitory molecules expressed by them, provides us with opportunities to generate DCs that are capable of hyper-activating cytotoxic T lymphocytes (CTLs) whilst they impact on regulatory T cells (Treg), which are now well established to be an important contributor to failure of cancer vaccines. In this chapter, we will focus on the cross talk between DCs and T cells mediated by the CD70/CD27 and PD-L1/PD-1 axis as these have been identified as critical pathways in the regulation of immunity versus tolerance." @default.
• W1528483417 created "2016-06-24" @default.
• W1528483417 creator A5040466984 @default.
• W1528483417 creator A5048780479 @default.
• W1528483417 creator A5058459287 @default.
• W1528483417 creator A5079534384 @default.
• W1528483417 creator A5091638762 @default.
• W1528483417 date "2014-05-29" @default.
• W1528483417 modified "2023-10-02" @default.
• W1528483417 title "Manipulating Immune Regulatory Pathways to Enhance T Cell Stimulation" @default.
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