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- W152852511 abstract "Publisher Summary This chapter discusses the epidemiology of the perinatal telencephalic leukoencephalopathy characterized by hypertrophic astrocytes and amphophilic globules. In an earlier analysis, increased risk of hypertrophic astrocytes and amphophilic globules was associated with six delivery variables. Induction of labor and oxytocic use, two separate variables which to a large extent may be measuring the same thing, were associated with increased risk. A greatly increased risk was seen in babies whose mothers had nonperineal lacerations. Babies who had marked molding of the head were also at increased risk, as were babies delivered after less than 8 hours of labor. The risk of hypertrophic astrocytes and amphophilic globules in telencephalic white matter tended to decrease with decreasing gestational age and birth weight. The postnatal findings associated with decreased risk included low Apgar scores, respiratory abnormalities, and severe ecchymoses. The organisms cultured from pregnant women with urinary tract infections tend to be enteric organisms that produce endotoxin. The occurrence of fever with these infections is additional support for the hypothesis that these women had circulating endotoxins, which probably crossed the placenta and adversely affected their fetuses' cerebral white matter." @default.
- W152852511 created "2016-06-24" @default.
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- W152852511 date "1983-01-01" @default.
- W152852511 modified "2023-10-16" @default.
- W152852511 title "THE EPIDEMIOLOGY OF THE PERINATAL TELENCEPHALIC LEUCOENCEPHALOPATHY CHARACTERIZED BY HYPERTROPHIC ASTROCYTES AND AMPHOPHILIC GLOBULES" @default.
- W152852511 doi "https://doi.org/10.1016/b978-0-7236-7017-9.50030-2" @default.
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