Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528606891> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1528606891 endingPage "12" @default.
- W1528606891 startingPage "1005" @default.
- W1528606891 abstract "Hyperprolactinemia is a common, but neglected, adverse effect of conventional antipschycotics and of some of the atypical antipshycotics. It occurs in almost 42% of men and in 75% of women with schizophrenia who are treated with prolactin-raising antipshycotics, even though it has aroused minimal interest within the scientific community when compared with extra-pyramidal effects. Conventional antipsychotics and some of the atypical antipsychotics, such as risperidone, paliperidone, amisulpride and zotepine, are frequently associated with the raise in prolactin plasma levels. Because of this increment in prolactin secretion, they are usually known as prolactin-raising antipshycotics. On the contrary, some of the atypical antipsychotics, such as clozapine, quetiapine, olanzapine, aripiprazole and ziprazidone, have a minimal or no significant effect in prolactin levels, being known as prolactin-sparing antipsychotics. Hyperprolactinemia clinical symptoms include gynaecomastia, galactorrhoea, menstrual irregularities, infertility, sexual dysfunction, acne and hirsutism. Some of these symptoms are due to the prolactin direct action in body tissues, while a couple of them can be due to a hypothalamic-pituitary-gonadal axis dysregulation mediated by the elevation of prolactin. Some studies seem to point the evidence of an association between hyperprolactinemia and long-term consequences, such as bone mineral density decrement and breast cancer. However, these results must be confirmed through further studies. Antipsychotic treatment is the most common cause of hyperprolactinemia in psychiatric patients. However, the evidence of a prolactin increased plasma level demands the differential diagnosis with other pathologies, such as hyphotalamic and pituitary neoplasic disease. The management of a patient with antipsychotic-induced hyperprolactinemia must be adapted to each patient and it may include a reduction in the dosage of the offending antipsychotic, switching to a prolactin-sparing antipsychotic or the use of a dopamine receptor agonist, such as bromocriptine, cabergoline and amantadine. Given the osteopenic and osteoporosis risk, combined oral contraceptives must be considered in female patients in fertile age which have amenorrhoea for at least a one year period. With the exception of the Maudsley Prescribing Guidelines and the National Collaborating Centre for Mental Health, none of the current international psychiatric guidelines recommend a routine baseline prolactin determination, neither periodic prolactin levels without the presence of any hyperprolactinemia symptoms." @default.
- W1528606891 created "2016-06-24" @default.
- W1528606891 creator A5048902490 @default.
- W1528606891 creator A5059075611 @default.
- W1528606891 date "2012-06-20" @default.
- W1528606891 modified "2023-09-22" @default.
- W1528606891 title "Hiperprolactinémia em doentes psiquiátricos." @default.
- W1528606891 doi "https://doi.org/10.20344/amp.1415" @default.
- W1528606891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22713195" @default.
- W1528606891 hasPublicationYear "2012" @default.
- W1528606891 type Work @default.
- W1528606891 sameAs 1528606891 @default.
- W1528606891 citedByCount "8" @default.
- W1528606891 countsByYear W15286068912013 @default.
- W1528606891 countsByYear W15286068912014 @default.
- W1528606891 countsByYear W15286068912015 @default.
- W1528606891 countsByYear W15286068912016 @default.
- W1528606891 countsByYear W15286068912017 @default.
- W1528606891 crossrefType "journal-article" @default.
- W1528606891 hasAuthorship W1528606891A5048902490 @default.
- W1528606891 hasAuthorship W1528606891A5059075611 @default.
- W1528606891 hasBestOaLocation W15286068911 @default.
- W1528606891 hasConcept C118552586 @default.
- W1528606891 hasConcept C126322002 @default.
- W1528606891 hasConcept C134018914 @default.
- W1528606891 hasConcept C2776412080 @default.
- W1528606891 hasConcept C2778093883 @default.
- W1528606891 hasConcept C2778999636 @default.
- W1528606891 hasConcept C2779064019 @default.
- W1528606891 hasConcept C2780057945 @default.
- W1528606891 hasConcept C2780211496 @default.
- W1528606891 hasConcept C2780494398 @default.
- W1528606891 hasConcept C2780634440 @default.
- W1528606891 hasConcept C2780864610 @default.
- W1528606891 hasConcept C2781401123 @default.
- W1528606891 hasConcept C71315377 @default.
- W1528606891 hasConcept C71924100 @default.
- W1528606891 hasConceptScore W1528606891C118552586 @default.
- W1528606891 hasConceptScore W1528606891C126322002 @default.
- W1528606891 hasConceptScore W1528606891C134018914 @default.
- W1528606891 hasConceptScore W1528606891C2776412080 @default.
- W1528606891 hasConceptScore W1528606891C2778093883 @default.
- W1528606891 hasConceptScore W1528606891C2778999636 @default.
- W1528606891 hasConceptScore W1528606891C2779064019 @default.
- W1528606891 hasConceptScore W1528606891C2780057945 @default.
- W1528606891 hasConceptScore W1528606891C2780211496 @default.
- W1528606891 hasConceptScore W1528606891C2780494398 @default.
- W1528606891 hasConceptScore W1528606891C2780634440 @default.
- W1528606891 hasConceptScore W1528606891C2780864610 @default.
- W1528606891 hasConceptScore W1528606891C2781401123 @default.
- W1528606891 hasConceptScore W1528606891C71315377 @default.
- W1528606891 hasConceptScore W1528606891C71924100 @default.
- W1528606891 hasIssue "6" @default.
- W1528606891 hasLocation W15286068911 @default.
- W1528606891 hasLocation W15286068912 @default.
- W1528606891 hasOpenAccess W1528606891 @default.
- W1528606891 hasPrimaryLocation W15286068911 @default.
- W1528606891 hasRelatedWork W100818451 @default.
- W1528606891 hasRelatedWork W1528606891 @default.
- W1528606891 hasRelatedWork W1975768376 @default.
- W1528606891 hasRelatedWork W1979888667 @default.
- W1528606891 hasRelatedWork W2032902988 @default.
- W1528606891 hasRelatedWork W2044400697 @default.
- W1528606891 hasRelatedWork W2125553860 @default.
- W1528606891 hasRelatedWork W2562095473 @default.
- W1528606891 hasRelatedWork W3185888555 @default.
- W1528606891 hasRelatedWork W1492837946 @default.
- W1528606891 hasVolume "24" @default.
- W1528606891 isParatext "false" @default.
- W1528606891 isRetracted "false" @default.
- W1528606891 magId "1528606891" @default.
- W1528606891 workType "article" @default.