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- W152867562 abstract "This chapter discusses various aspects of multicombinatorial libraries and combinatorial infection. The antibody phage display can provide direct and easy access to human antibodies and the possibility of generating anti-self antibodies. The lox -Cre system of bacteriophage P1 has already been tested for the assembly of two different vectors. Using this approach, antibody libraries with a size more representative of the natural immune repertoire have been obtained. A circular form of bacteriophage h integrates into the bacterial chromosome during the establishment of lysogeny. Two sequences are involved in intermolecular recombination, a 240-bp phage-encoded attP-specific site and a 23-bp attB site in the bacterial chromosome. Upon recombination, one can obtain a new phagemid (pM835) carrying both the antibody chains or encoded peptides and characterized by the functional association of the cat resistance gene with its promoter. Different aspects of the recombination process were successively analyzed, and the functionality was assessed in terms of recombination efficiency, infectivity, and ability to express soluble molecules. The att system has been proven to be a very efficient means of inducing the irreversible association between two vector partners. It is suggested that the association of variable polypeptides encoded on two different vectors gives access to unexpected experiments such as the improvement of binding affinity of heterodimeric receptors, and many other experiments involving the coexpression of two polymorphic molecules." @default.
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- W152867562 date "1996-01-01" @default.
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- W152867562 title "Multicombinatorial Libraries and Combinatorial Infection: Practical Considerations for Vector Design" @default.
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