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• W1528714917 abstract "Novel pyrone-derived quorum sensing (QS) ligands to inhibit the binding of OdDHL to the LasR of Pseudomonas aeruginosa were designed, synthesized and evaluated. Among the analogs, the most potent compound 8 exhibited strong in vitro inhibitory activities against biofilm formation and down-regulated OdDHL/LasR-associated genes by 35-67%. The binding mode of 8 in silico was highly similar to that of the crystal ligand OdDHL in the active site of LasR." @default.
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• W1528714917 date "2015-08-01" @default.
• W1528714917 modified "2023-10-15" @default.
• W1528714917 title "Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors" @default.
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• W1528714917 doi "https://doi.org/10.1016/j.bmcl.2015.05.054" @default.
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