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• W1528734764 abstract "Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications." @default.
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• W1528734764 date "1997-08-01" @default.
• W1528734764 modified "2023-10-18" @default.
• W1528734764 title "Functional management of an antiviral cytotoxic T-cell response" @default.
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• W1528734764 doi "https://doi.org/10.1128/jvi.71.8.5764-5768.1997" @default.
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