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• W1528745384 abstract "Stem cells are a rare population of cells that have the ability to self-renew (to replenish the stem cell pool) and to differentiate (to produce daughter cells that will perform the physiological functions of tissues and organs). Although stem cells exist in different tissues, organs, and developmental stages. However, stem cells differ to some degree with regard to their developmental potency; life span, and notably their potential for self-renewal and proliferation capacity. Stem cell self-renewal and differentiation is regulated by signaling pathways, transcription factors, and micro RNAs (miRNAs). Some key transcription factors directly regulate the expression of miRNAs in stem cells. Meanwhile, miRNAs target key transcription factors and either repress or induce their expression in stem cells to regulate self-renewal and differentiation. Thereby, the miRNA regulatory network and the signaling pathways crosstalk to each other to orchestrate stem cell maintenance and cell fate decision. Dysregulation of core signaling pathways, transcription factors and miRNAs associated with normal stem cells can lead to carcinogenesis. Thus, understanding the regulation of normal stem cell is crucial for understanding the molecular mechanisms underline carcinogenesis. In this chapter, we review the characteristics and functions of miRNAs and cancer stem cells (CSCs), focusing on the roles of miRNAs in regulating CSCs. First, we provide an introduction to stem cells and CSCs. Then, we describe the signaling pathways that regulate stem cell self-renewal and differentiation. In particular, we review the Wnt/┚-catenin, Hedgehog (HH), and Notch pathways. Next, we discuss the epithelial–mesenchymal transition (EMT), CSCs, and miRNAs that play roles in regulating stem cells. Finally, we summarize the current status and discuss future perspectives." @default.
• W1528745384 created "2016-06-24" @default.
• W1528745384 creator A5028989565 @default.
• W1528745384 creator A5030437475 @default.
• W1528745384 date "2011-08-23" @default.
• W1528745384 modified "2023-10-14" @default.
• W1528745384 title "The Role of MicroRNAs in Regulating Cancer Stem Cells" @default.
• W1528745384 cites W144423133 @default.
• W1528745384 cites W1484268538 @default.
• W1528745384 cites W1498970130 @default.
• W1528745384 cites W1505671001 @default.
• W1528745384 cites W1507798874 @default.
• W1528745384 cites W1544465315 @default.
• W1528745384 cites W1596473475 @default.
• W1528745384 cites W1648301895 @default.
• W1528745384 cites W1816761971 @default.
• W1528745384 cites W1861988602 @default.
• W1528745384 cites W1920303762 @default.
• W1528745384 cites W1964081206 @default.
• W1528745384 cites W1964742669 @default.
• W1528745384 cites W1969142310 @default.
• W1528745384 cites W1969380521 @default.
• W1528745384 cites W1975437957 @default.
• W1528745384 cites W1976324983 @default.
• W1528745384 cites W1977297606 @default.
• W1528745384 cites W1977480736 @default.
• W1528745384 cites W1979364059 @default.
• W1528745384 cites W1980415581 @default.
• W1528745384 cites W1982969810 @default.
• W1528745384 cites W1984214021 @default.
• W1528745384 cites W1984948591 @default.
• W1528745384 cites W1985839640 @default.
• W1528745384 cites W1986903527 @default.
• W1528745384 cites W1989619365 @default.
• W1528745384 cites W1990563353 @default.
• W1528745384 cites W1990577927 @default.
• W1528745384 cites W1992193555 @default.
• W1528745384 cites W1992676863 @default.
• W1528745384 cites W1992803636 @default.
• W1528745384 cites W1993416164 @default.
• W1528745384 cites W1994183300 @default.
• W1528745384 cites W1994649597 @default.
• W1528745384 cites W1995940184 @default.
• W1528745384 cites W1996331932 @default.
• W1528745384 cites W1996339633 @default.
• W1528745384 cites W1996835079 @default.
• W1528745384 cites W1997379399 @default.
• W1528745384 cites W1999636129 @default.
• W1528745384 cites W2000093333 @default.
• W1528745384 cites W2002179012 @default.
• W1528745384 cites W2002341492 @default.
• W1528745384 cites W2004419844 @default.
• W1528745384 cites W2006169630 @default.
• W1528745384 cites W2009094422 @default.
• W1528745384 cites W2010031978 @default.
• W1528745384 cites W2010215928 @default.
• W1528745384 cites W2010257495 @default.
• W1528745384 cites W2010653264 @default.
• W1528745384 cites W2012758718 @default.
• W1528745384 cites W2014126877 @default.
• W1528745384 cites W2014426141 @default.
• W1528745384 cites W2014490965 @default.
• W1528745384 cites W2014691022 @default.
• W1528745384 cites W2015858554 @default.
• W1528745384 cites W2015974087 @default.
• W1528745384 cites W2016931709 @default.
• W1528745384 cites W2018330645 @default.
• W1528745384 cites W2019264784 @default.
• W1528745384 cites W2020833650 @default.
• W1528745384 cites W2021050536 @default.
• W1528745384 cites W2024704386 @default.
• W1528745384 cites W2029073164 @default.
• W1528745384 cites W2031688735 @default.
• W1528745384 cites W2035690311 @default.
• W1528745384 cites W2036224487 @default.
• W1528745384 cites W2037290810 @default.
• W1528745384 cites W2039756909 @default.
• W1528745384 cites W2042082068 @default.
• W1528745384 cites W2043772793 @default.
• W1528745384 cites W2044303467 @default.
• W1528745384 cites W2045089484 @default.
• W1528745384 cites W2045414448 @default.
• W1528745384 cites W2045456080 @default.
• W1528745384 cites W2045998598 @default.
• W1528745384 cites W2052767351 @default.
• W1528745384 cites W2053490054 @default.
• W1528745384 cites W2056105211 @default.
• W1528745384 cites W2057289143 @default.
• W1528745384 cites W2059456940 @default.
• W1528745384 cites W2061491996 @default.
• W1528745384 cites W2063011414 @default.
• W1528745384 cites W2063478423 @default.
• W1528745384 cites W2065492865 @default.
• W1528745384 cites W2068834637 @default.
• W1528745384 cites W2069068158 @default.
• W1528745384 cites W2069381736 @default.
• W1528745384 cites W2075904779 @default.
• W1528745384 cites W2076681174 @default.
• W1528745384 cites W2078448971 @default.
• W1528745384 cites W2080480789 @default.

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