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- W1528769438 abstract "Experiments were performed to study the response of rat-brain and rat-liver ribosomes to various metabolites and inhibitors that are known to affect amino acid incorporation by interfering with one or more steps in the sequence of protein biosynthesis. Some quantitative and qualitative differences were noted in the effects of these compounds depending on the tissue source of the ribosomes, the age of the tissue and whether the amino acid was incorporated by ribosomes into protein or into poly-U-directed polyphenylalanine. Chloramphenicol slightly enhanced the incorporation into brain ribosomal protein while it depressed the incorporation into polyphenylalanine, the extent of this depression being dependent upon the age of the tissue. The results suggest that this antibiotic acts by inhibiting the attachment of mRNA to ribosomes, but it has no effect after this attachment has taken place. The oxidized form of glutathione (GSSG) and cystine were found to be very inhibitory when added to the reaction mixture. This inhibition was not counteracted by simultaneous additions of NAD+, NADP+, NADH, or NADPH. On the other hand, these coenzymes themselves produced inhibition of phenylalanine incorporation. Reaction mixtures containing the inhibitory-sulfur compounds, did not accumulate phenylalanyl sRNA. On the contrary, incorporation into sRNA was inhibited by these compounds and this inhibition corresponded closely with their inhibition of protein synthesis. This is taken to indicate that the primary effect of these compounds on the incorporation mechanism consists in their action on the amino acid activation step." @default.
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- W1528769438 date "1966-06-01" @default.
- W1528769438 modified "2023-10-17" @default.
- W1528769438 title "Protein synthesis in growing rat tissues" @default.
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- W1528769438 doi "https://doi.org/10.1016/0005-2787(66)90135-3" @default.
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