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- W1528773087 abstract "This chapter describes the chemical biological approach directed at investigating delta subunit of phosphodiesterase (PDEδ) as a prenyl-binding protein and for characterizing its role in sustaining Ras protein function and localization in cells. Ras proteins are involved in many cellular processes regulating cell proliferation and differentiation. The chapter discusses a chemical biological approach that gives access to fully lipidated K-Ras4B proteins, thereby enabling the study of its interaction with PDEδ and the characterization of the role of PDEδ in maintaining K-Ras distribution and function in the cell. The gained information could be used for the establishment of a screening assay aimed to identify small-molecule inhibitors able to block this interaction and, in consequence, oncogenic Ras signaling." @default.
- W1528773087 created "2016-06-24" @default.
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- W1528773087 date "2014-06-27" @default.
- W1528773087 modified "2023-09-24" @default.
- W1528773087 title "Inhibition of Oncogenic K-Ras Signaling by Targeting K-Ras-PDEδ Interaction" @default.
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- W1528773087 doi "https://doi.org/10.1002/9783527687503.ch7" @default.
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