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- W1528851512 abstract "Fc fragments of Ig induce blastogenesis, proliferation, and polyclonal antibody production in murine B lymphocytes. Enrichment for complement receptor-bearing (CR+) spleen cells from normal mice consistently results in a threefold increase of the proliferative response (measured by [3H]thymidine incorporation). In contrast, spleen cells or CR+ spleen cells from young adult mutant CBA/N mice cannot be triggered by Fc fragments while they are capable of responding to LPS. However, this defect is overcome in aging (1-year-old) CBA/N mice. In normal mice (A/J, CBA/Caj) responsiveness in spleen cells is absent at birth and gradually develops between 5 days and 8 weeks of age. This process also occurs, but is greatly delayed, in the mutant CBA/N strain. The findings suggest that the Fc signal for proliferation acts on B cells at a late stage of maturation." @default.
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- W1528851512 date "1980-07-01" @default.
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- W1528851512 title "Lymphocyte stimulation with Fc fragments" @default.
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- W1528851512 doi "https://doi.org/10.1016/0008-8749(80)90355-x" @default.
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