FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528852596> ?p ?o ?g. }

• W1528852596 abstract "The poly(ADP-ribose) polymerase (PARP) family of proteins use NAD(+) as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under physiological conditions is unknown. Here, to better understand this protein family, we systematically analyse the cell cycle localization of each PARP and of poly(ADP-ribose), a product of PARP activity, then identify the knockdown phenotype of each protein and perform secondary assays to elucidate function. We show that most PARPs are cytoplasmic, identify cell cycle differences in the ratio of nuclear to cytoplasmic poly(ADP-ribose) and identify four phenotypic classes of PARP function. These include the regulation of membrane structures, cell viability, cell division and the actin cytoskeleton. Further analysis of PARP14 shows that it is a component of focal adhesion complexes required for proper cell motility and focal adhesion function. In total, we show that PARP proteins are critical regulators of eukaryotic physiology." @default.
• W1528852596 created "2016-06-24" @default.
• W1528852596 creator A5027261690 @default.
• W1528852596 creator A5030073669 @default.
• W1528852596 creator A5052888498 @default.
• W1528852596 creator A5060706661 @default.
• W1528852596 creator A5067070698 @default.
• W1528852596 date "2013-08-01" @default.
• W1528852596 modified "2023-09-23" @default.
• W1528852596 title "A systematic analysis of the PARP protein family identifies new functions critical for cell physiology" @default.
• W1528852596 cites W1848063234 @default.
• W1528852596 cites W1970166276 @default.
• W1528852596 cites W1971622025 @default.
• W1528852596 cites W1990946891 @default.
• W1528852596 cites W2008952211 @default.
• W1528852596 cites W2010445535 @default.
• W1528852596 cites W2022350916 @default.
• W1528852596 cites W2025550674 @default.
• W1528852596 cites W2030939970 @default.
• W1528852596 cites W2035895891 @default.
• W1528852596 cites W2040206596 @default.
• W1528852596 cites W2047844649 @default.
• W1528852596 cites W2053110665 @default.
• W1528852596 cites W2057706543 @default.
• W1528852596 cites W2058058143 @default.
• W1528852596 cites W2065455422 @default.
• W1528852596 cites W2075322420 @default.
• W1528852596 cites W2078651829 @default.
• W1528852596 cites W2086038769 @default.
• W1528852596 cites W2087556842 @default.
• W1528852596 cites W2099283261 @default.
• W1528852596 cites W2102647168 @default.
• W1528852596 cites W2109512616 @default.
• W1528852596 cites W2111711361 @default.
• W1528852596 cites W2147138972 @default.
• W1528852596 cites W2150645494 @default.
• W1528852596 cites W2154465669 @default.
• W1528852596 cites W2158389792 @default.
• W1528852596 cites W2168496620 @default.
• W1528852596 cites W2169274959 @default.
• W1528852596 cites W2430853496 @default.
• W1528852596 cites W560616259 @default.
• W1528852596 hasPublicationYear "2013" @default.
• W1528852596 type Work @default.
• W1528852596 sameAs 1528852596 @default.
• W1528852596 citedByCount "0" @default.
• W1528852596 crossrefType "journal-article" @default.
• W1528852596 hasAuthorship W1528852596A5027261690 @default.
• W1528852596 hasAuthorship W1528852596A5030073669 @default.
• W1528852596 hasAuthorship W1528852596A5052888498 @default.
• W1528852596 hasAuthorship W1528852596A5060706661 @default.
• W1528852596 hasAuthorship W1528852596A5067070698 @default.
• W1528852596 hasConcept C1491633281 @default.
• W1528852596 hasConcept C181199279 @default.
• W1528852596 hasConcept C182979987 @default.
• W1528852596 hasConcept C190062978 @default.
• W1528852596 hasConcept C191141034 @default.
• W1528852596 hasConcept C29537977 @default.
• W1528852596 hasConcept C552990157 @default.
• W1528852596 hasConcept C55493867 @default.
• W1528852596 hasConcept C75520062 @default.
• W1528852596 hasConcept C82381507 @default.
• W1528852596 hasConcept C86803240 @default.
• W1528852596 hasConcept C95444343 @default.
• W1528852596 hasConceptScore W1528852596C1491633281 @default.
• W1528852596 hasConceptScore W1528852596C181199279 @default.
• W1528852596 hasConceptScore W1528852596C182979987 @default.
• W1528852596 hasConceptScore W1528852596C190062978 @default.
• W1528852596 hasConceptScore W1528852596C191141034 @default.
• W1528852596 hasConceptScore W1528852596C29537977 @default.
• W1528852596 hasConceptScore W1528852596C552990157 @default.
• W1528852596 hasConceptScore W1528852596C55493867 @default.
• W1528852596 hasConceptScore W1528852596C75520062 @default.
• W1528852596 hasConceptScore W1528852596C82381507 @default.
• W1528852596 hasConceptScore W1528852596C86803240 @default.
• W1528852596 hasConceptScore W1528852596C95444343 @default.
• W1528852596 hasLocation W15288525961 @default.
• W1528852596 hasOpenAccess W1528852596 @default.
• W1528852596 hasPrimaryLocation W15288525961 @default.
• W1528852596 hasRelatedWork W1540113711 @default.
• W1528852596 hasRelatedWork W1963982942 @default.
• W1528852596 hasRelatedWork W2036793307 @default.
• W1528852596 hasRelatedWork W2042725479 @default.
• W1528852596 hasRelatedWork W2046338307 @default.
• W1528852596 hasRelatedWork W2072250112 @default.
• W1528852596 hasRelatedWork W2105666223 @default.
• W1528852596 hasRelatedWork W2113699634 @default.
• W1528852596 hasRelatedWork W2155208299 @default.
• W1528852596 hasRelatedWork W2342744207 @default.
• W1528852596 hasRelatedWork W2533433563 @default.
• W1528852596 hasRelatedWork W2551954408 @default.
• W1528852596 hasRelatedWork W2604136844 @default.
• W1528852596 hasRelatedWork W2766471599 @default.
• W1528852596 hasRelatedWork W2927462596 @default.
• W1528852596 hasRelatedWork W3099091528 @default.
• W1528852596 hasRelatedWork W3120579778 @default.
• W1528852596 hasRelatedWork W3185888647 @default.
• W1528852596 hasRelatedWork W5111038 @default.
• W1528852596 hasRelatedWork W1953332 @default.
• W1528852596 isParatext "false" @default.

• next