FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1528927459> ?p ?o ?g. }

• W1528927459 abstract "Insulinoma-associated protein 1 (INSM1) is a zinc finger transcriptional repressor with a limited spatial and temporal embryonic expression pattern in neuronal and neuroendocrine tissues. Interestingly, INSM1 activity is reactivated in neuroendocrine tumors such as small-cell lung cancer (SCLC), neuroblastoma, medulloblastoma, and retinoblastoma. Adenoviral constructs with the 1.7-kilobase pair INSM1 promoter-driven herpes simplex virus thymidine kinase (HSV-tk) gene could effectively suppress D283 Med subcutaneous xenograft tumor growth. Undesirably, sequences in the adenoviral backbone overrode promoter specificity in vivo. Incorporation of both the chicken β-globin HS4 insulator sequence and 2 copies of the mouse nicotinic acetylcholine receptor (nAchR) neuronal restrictive silencer element abolished the nonspecific activation of the INSM1 promoter in vivo.The luciferase reporter gene was replaced with the HSV-tk suicide gene to generate the Ad-K5 virus. Both in vitro cell viability assays and in vivo tumor regression studies were used to determine the efficacy of the improved configuration INSM1 promoter adenoviral construct against a panel of neuroendocrine cell lines.In vitro cell viability assays with the Ad-K5 HSV-tk-expressing construct further reinforced that the Ad-K5 virus could eradicate SCLC, insulinoma, medulloblastoma, and neuroblastoma cells. Further, Ad-K5 virus treatment of a D283 Med subcutaneous xenograft tumor showed a superior antitumor effect over the control Ad-RSV (Rous sarcoma virus)-HSV-tk.Improvements to the INSM1 promoter resulted in a stronger and more selective adenovirus. Treatment of a panel of neuroendocrine carcinomas with the Ad-K5 virus revealed enhanced antitumor activity over the RSV control, demonstrating its usefulness for the treatment of a variety of neuroendocrine tumors." @default.
• W1528927459 created "2016-06-24" @default.
• W1528927459 creator A5024559901 @default.
• W1528927459 creator A5031611361 @default.
• W1528927459 creator A5040758427 @default.
• W1528927459 creator A5049523575 @default.
• W1528927459 date "2013-01-01" @default.
• W1528927459 modified "2023-09-22" @default.
• W1528927459 title "Adenoviral insulinoma-associated protein 1 promoter-driven suicide gene therapy with enhanced selectivity for treatment of neuroendocrine cancers." @default.
• W1528927459 cites W1549694960 @default.
• W1528927459 cites W1975792133 @default.
• W1528927459 cites W1978265030 @default.
• W1528927459 cites W1981866448 @default.
• W1528927459 cites W1985759990 @default.
• W1528927459 cites W2010502399 @default.
• W1528927459 cites W2017614842 @default.
• W1528927459 cites W2027873230 @default.
• W1528927459 cites W2059348160 @default.
• W1528927459 cites W2062548336 @default.
• W1528927459 cites W2063643192 @default.
• W1528927459 cites W2067493801 @default.
• W1528927459 cites W2104741209 @default.
• W1528927459 cites W2119580535 @default.
• W1528927459 cites W2120118075 @default.
• W1528927459 cites W2138842865 @default.
• W1528927459 cites W2144579032 @default.
• W1528927459 cites W2163416892 @default.
• W1528927459 cites W2165243257 @default.
• W1528927459 cites W2316737784 @default.
• W1528927459 cites W2330817253 @default.
• W1528927459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3603194" @default.
• W1528927459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23533081" @default.
• W1528927459 hasPublicationYear "2013" @default.
• W1528927459 type Work @default.
• W1528927459 sameAs 1528927459 @default.
• W1528927459 citedByCount "7" @default.
• W1528927459 countsByYear W15289274592013 @default.
• W1528927459 countsByYear W15289274592014 @default.
• W1528927459 countsByYear W15289274592015 @default.
• W1528927459 countsByYear W15289274592016 @default.
• W1528927459 countsByYear W15289274592018 @default.
• W1528927459 countsByYear W15289274592019 @default.
• W1528927459 crossrefType "journal-article" @default.
• W1528927459 hasAuthorship W1528927459A5024559901 @default.
• W1528927459 hasAuthorship W1528927459A5031611361 @default.
• W1528927459 hasAuthorship W1528927459A5040758427 @default.
• W1528927459 hasAuthorship W1528927459A5049523575 @default.
• W1528927459 hasConcept C104317684 @default.
• W1528927459 hasConcept C111335760 @default.
• W1528927459 hasConcept C111599444 @default.
• W1528927459 hasConcept C153911025 @default.
• W1528927459 hasConcept C159047783 @default.
• W1528927459 hasConcept C207001950 @default.
• W1528927459 hasConcept C24284526 @default.
• W1528927459 hasConcept C2522874641 @default.
• W1528927459 hasConcept C2781196997 @default.
• W1528927459 hasConcept C32470452 @default.
• W1528927459 hasConcept C34981463 @default.
• W1528927459 hasConcept C40767141 @default.
• W1528927459 hasConcept C502942594 @default.
• W1528927459 hasConcept C54009773 @default.
• W1528927459 hasConcept C54355233 @default.
• W1528927459 hasConcept C71924100 @default.
• W1528927459 hasConcept C86339819 @default.
• W1528927459 hasConcept C86803240 @default.
• W1528927459 hasConceptScore W1528927459C104317684 @default.
• W1528927459 hasConceptScore W1528927459C111335760 @default.
• W1528927459 hasConceptScore W1528927459C111599444 @default.
• W1528927459 hasConceptScore W1528927459C153911025 @default.
• W1528927459 hasConceptScore W1528927459C159047783 @default.
• W1528927459 hasConceptScore W1528927459C207001950 @default.
• W1528927459 hasConceptScore W1528927459C24284526 @default.
• W1528927459 hasConceptScore W1528927459C2522874641 @default.
• W1528927459 hasConceptScore W1528927459C2781196997 @default.
• W1528927459 hasConceptScore W1528927459C32470452 @default.
• W1528927459 hasConceptScore W1528927459C34981463 @default.
• W1528927459 hasConceptScore W1528927459C40767141 @default.
• W1528927459 hasConceptScore W1528927459C502942594 @default.
• W1528927459 hasConceptScore W1528927459C54009773 @default.
• W1528927459 hasConceptScore W1528927459C54355233 @default.
• W1528927459 hasConceptScore W1528927459C71924100 @default.
• W1528927459 hasConceptScore W1528927459C86339819 @default.
• W1528927459 hasConceptScore W1528927459C86803240 @default.
• W1528927459 hasLocation W15289274591 @default.
• W1528927459 hasOpenAccess W1528927459 @default.
• W1528927459 hasPrimaryLocation W15289274591 @default.
• W1528927459 hasRelatedWork W110319290 @default.
• W1528927459 hasRelatedWork W1979777344 @default.
• W1528927459 hasRelatedWork W1988912149 @default.
• W1528927459 hasRelatedWork W1999405337 @default.
• W1528927459 hasRelatedWork W1999429473 @default.
• W1528927459 hasRelatedWork W2000016124 @default.
• W1528927459 hasRelatedWork W2025639910 @default.
• W1528927459 hasRelatedWork W2037292820 @default.
• W1528927459 hasRelatedWork W2037754932 @default.
• W1528927459 hasRelatedWork W2038325417 @default.
• W1528927459 hasRelatedWork W2046239991 @default.
• W1528927459 hasRelatedWork W2059348160 @default.
• W1528927459 hasRelatedWork W2071633053 @default.
• W1528927459 hasRelatedWork W2086181409 @default.

• next