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- W1528992489 abstract "Xnot-2 is a homeobox gene expressed in Spemann's organizer. Here we present evidence that microinjection of synthetic Xnot-2 mRNA leads to the formation of notochord. Microinjection into the dorsal side of the Xenopus embryo results in greatly expanded notochords. Nearby somitic and prechordal mesoderm becomes recruited into these enlarged notochords, which also affect CNS patterning. Two early genes expressed in the developing notochord, chd and XFKH-1, are activated by Xnot-2. We conclude that gain-of-function of Xnot-2 promotes notochord formation." @default.
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- W1528992489 date "1996-02-01" @default.
- W1528992489 modified "2023-10-18" @default.
- W1528992489 title "Overexpression of the Homeobox GeneXnot-2Leads to Notochord Formation inXenopus" @default.
- W1528992489 doi "https://doi.org/10.1006/dbio.1996.0061" @default.
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