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- W1529024588 abstract "The majority of data are consistent with the idea that plasticity mechanisms in the hippocampus are altered, as is spatial cognition, during aging. A number of studies, including several to which Frank Morrell contributed, show that the age-related changes in these neural and behavioral variables are significantly correlated and that they can be manipulated in a way such that older animals show more effective brain plasticity and more accurate spatial behavior. Frank Morrell was very interested in how plasticity mechanisms are altered during aging and how these changes may affect cognition. This chapter summarizes the progress to date in the understanding of how long-term potentiation (LTP) and other plasticity characteristics of the hippocampus are altered by the aging process and how this may relate to learning and memory alterations during aging, which includes the experimental work that Frank Morrell contributed to this area of scientific inquiry. Challenge now is to move these basic research facts into clinical application." @default.
- W1529024588 created "2016-06-24" @default.
- W1529024588 creator A5042422785 @default.
- W1529024588 date "2001-01-01" @default.
- W1529024588 modified "2023-10-14" @default.
- W1529024588 title "Plasticity in the aging central nervous system" @default.
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- W1529024588 doi "https://doi.org/10.1016/s0074-7742(01)45018-5" @default.
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