FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529032080> ?p ?o ?g. }

• W1529032080 endingPage "3939" @default.
• W1529032080 startingPage "3931" @default.
• W1529032080 abstract "The inverted terminal repeat (ITR) of adenovirus type 5 (Ad5) is 103 bp in length and contains the origin of DNA replication. Cellular transcription factors NFI/CTF and NFIII/OCT-1 bind to sites within the ITR and participate in the initiation of viral DNA replication in vitro. The ITR also contains multiple copies of two conserved sequence motifs that bind the cellular transcription factors SP1 and ATF. We have analyzed a series of viruses that carry deletions at the left terminus of Ad5. A virus carrying a deletion of the NFIII/OCT-1, SP1, and ATF sites within the ITR (mutant dl309-44/107) was wild type for virus growth. However, the deletion of these elements in addition to sequences immediately flanking the ITR (mutant dl309-44/195) resulted in a virus that grew poorly. The analysis of growth parameters of these and other mutants demonstrate that the NFIII/OCT-1 and adjacent SP1 sites augment the accumulation of viral DNA following infection. The function of these elements was most evident in coinfections with a wild-type virus, suggesting that these sites enhance the ability of a limiting trans-acting factor(s), that stimulates viral DNA replication, to interact with the ITR. The results of these analyses indicate functional redundancy between different transcription elements at the left terminus of the Ad5 genome and demonstrate that the NFIII/OCT-1 site and adjacent SP1 site, previously thought to be nonessential for adenovirus growth, play a role in viral DNA replication in vivo." @default.
• W1529032080 created "2016-06-24" @default.
• W1529032080 creator A5060909412 @default.
• W1529032080 creator A5063322136 @default.
• W1529032080 date "1993-07-01" @default.
• W1529032080 modified "2023-09-27" @default.
• W1529032080 title "The NFIII/OCT-1 binding site stimulates adenovirus DNA replication in vivo and is functionally redundant with adjacent sequences" @default.
• W1529032080 cites W1484339355 @default.
• W1529032080 cites W1489610462 @default.
• W1529032080 cites W1499210329 @default.
• W1529032080 cites W1544608701 @default.
• W1529032080 cites W1567084122 @default.
• W1529032080 cites W1578555932 @default.
• W1529032080 cites W1614564740 @default.
• W1529032080 cites W1769491929 @default.
• W1529032080 cites W1775647714 @default.
• W1529032080 cites W1820433267 @default.
• W1529032080 cites W1834539294 @default.
• W1529032080 cites W1888427682 @default.
• W1529032080 cites W1914671017 @default.
• W1529032080 cites W1933950034 @default.
• W1529032080 cites W1951802529 @default.
• W1529032080 cites W1963587929 @default.
• W1529032080 cites W1964850387 @default.
• W1529032080 cites W1966384509 @default.
• W1529032080 cites W1968102812 @default.
• W1529032080 cites W1975473030 @default.
• W1529032080 cites W1976923854 @default.
• W1529032080 cites W1992200158 @default.
• W1529032080 cites W2003893812 @default.
• W1529032080 cites W2007281794 @default.
• W1529032080 cites W2009230618 @default.
• W1529032080 cites W2014669590 @default.
• W1529032080 cites W2019380681 @default.
• W1529032080 cites W2038277626 @default.
• W1529032080 cites W2044296969 @default.
• W1529032080 cites W2060853110 @default.
• W1529032080 cites W2079327210 @default.
• W1529032080 cites W2092216600 @default.
• W1529032080 cites W2093897768 @default.
• W1529032080 cites W2094154951 @default.
• W1529032080 cites W2099341388 @default.
• W1529032080 cites W2101448549 @default.
• W1529032080 cites W2122012163 @default.
• W1529032080 cites W2142807370 @default.
• W1529032080 cites W2159847993 @default.
• W1529032080 cites W2171917386 @default.
• W1529032080 cites W2324006254 @default.
• W1529032080 cites W2443338041 @default.
• W1529032080 cites W297134298 @default.
• W1529032080 cites W342448828 @default.
• W1529032080 cites W4246528186 @default.
• W1529032080 cites W71658991 @default.
• W1529032080 cites W9260168 @default.
• W1529032080 doi "https://doi.org/10.1128/jvi.67.7.3931-3939.1993" @default.
• W1529032080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/237760" @default.
• W1529032080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8510211" @default.
• W1529032080 hasPublicationYear "1993" @default.
• W1529032080 type Work @default.
• W1529032080 sameAs 1529032080 @default.
• W1529032080 citedByCount "52" @default.
• W1529032080 countsByYear W15290320802012 @default.
• W1529032080 countsByYear W15290320802013 @default.
• W1529032080 countsByYear W15290320802016 @default.
• W1529032080 countsByYear W15290320802017 @default.
• W1529032080 countsByYear W15290320802018 @default.
• W1529032080 countsByYear W15290320802019 @default.
• W1529032080 countsByYear W15290320802021 @default.
• W1529032080 crossrefType "journal-article" @default.
• W1529032080 hasAuthorship W1529032080A5060909412 @default.
• W1529032080 hasAuthorship W1529032080A5063322136 @default.
• W1529032080 hasBestOaLocation W15290320801 @default.
• W1529032080 hasConcept C104317684 @default.
• W1529032080 hasConcept C138885662 @default.
• W1529032080 hasConcept C140704245 @default.
• W1529032080 hasConcept C143065580 @default.
• W1529032080 hasConcept C151158763 @default.
• W1529032080 hasConcept C153911025 @default.
• W1529032080 hasConcept C159047783 @default.
• W1529032080 hasConcept C179926584 @default.
• W1529032080 hasConcept C2522874641 @default.
• W1529032080 hasConcept C2776954459 @default.
• W1529032080 hasConcept C40767141 @default.
• W1529032080 hasConcept C41895202 @default.
• W1529032080 hasConcept C54355233 @default.
• W1529032080 hasConcept C552990157 @default.
• W1529032080 hasConcept C73573662 @default.
• W1529032080 hasConcept C86803240 @default.
• W1529032080 hasConcept C95444343 @default.
• W1529032080 hasConcept C98086919 @default.
• W1529032080 hasConceptScore W1529032080C104317684 @default.
• W1529032080 hasConceptScore W1529032080C138885662 @default.
• W1529032080 hasConceptScore W1529032080C140704245 @default.
• W1529032080 hasConceptScore W1529032080C143065580 @default.
• W1529032080 hasConceptScore W1529032080C151158763 @default.
• W1529032080 hasConceptScore W1529032080C153911025 @default.
• W1529032080 hasConceptScore W1529032080C159047783 @default.
• W1529032080 hasConceptScore W1529032080C179926584 @default.

• next