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- W1529041857 abstract "Although neocarzinostatin (NCS) attacks DNA almost exclusively at adenine and thymine residues in vitro, exposure of Escherichia coli to this antitumor drug resulted in a high frequency of mutations at guanine:cytosine base pairs in the lacI gene. Thus, NCS-induced base substitution mutations do not appear to result from the major DNA lesions that have been biochemically characterized. The overall distribution of nonsense mutations produced by NCS was distinctly nonrandom, consisting in part of a few hotspots and a large number of coldspots. The existence of these coldspots implies that untargeted mutagenesis does not make a significant contribution to the mutations induced by this SOS-dependent mutagen." @default.
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- W1529041857 date "1983-01-01" @default.
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- W1529041857 title "Distribution and specificity of mutations induced by neocarzinostatin in the lacI gene of Escherichia coli" @default.
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- W1529041857 doi "https://doi.org/10.1128/jb.153.1.379-383.1983" @default.
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